IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells - Nature Communications Here, the authors show that IRX3 is a transcriptional master regulator of multiple histone- and chromatin-remodeling enzymes and the SUMOylation pathway in adipocyte precursor cells. IRX3 ablation res...

New publication @chymkowitchlab.bsky.social about how #IRX3 regulates adipocyte fate by influencing #epigenetic reprogramming, through modulating #SUMOylation and #chromatin remodeling, impacting fat storage and mesenchymal identity while suppressing osteogenesis.
Published in @natcomms.nature.com

Epigenetics Update - IRX3 controls a SUMOylation-dependent differentiation switch in adipocyte precursor cells go.nature.com/45s8wyx

#Epigenetics #IRX3 #Adipogenesis
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