The Insulin/IGF-1 pathway = master switch between growth & longevity 🔀

↓ IIS = longer life in worms, flies, mice (20-100% extension)
↑ IIS = growth, metabolism, but accelerated aging

Key mechanisms when IIS is reduced:
✅ FOXO activation → stress resistance

#Longevity #InsulinSignaling #Aging

RESEARCH COMMUNICATION: Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion
By Altun et. al and Siegfried Ussar
➡️ https://genesdev.cshlp.org/content/39/23-24/1414.full

#adipose #stemcells #adipogenesis #insulinsignaling #celldifferentiation #IGF

The neuropeptide neuromedin U receptor nmur-1 buffers insulin receptor signaling in bacteria-dependent C. elegans survival
Alcedo, J., Ch'ng, Q. et al.
Paper
Details
#NeuromedinUR #InsulinSignaling #C_elegansResearch

Folate Deficiency: DNA Damage Risk - Rhonda Patrick on DOAC

#dnadamage #insulinsignaling #folate #longevity

Exercise improves brain function, possibly reducing dementia risk – BioNews Central Study shows that specialized cells involved in insulin signaling are activated in the brain after exercise, suggesting that physical activity may directly improve brain function. ...

Study shows that specialized cells involved in #InsulinSignaling are activated in the #brain after #exercise, suggesting that #PhysicalActivity may directly improve #BrainFunction.
#OlderAdults #InsulinSensitivity #Type2Diabetes #Dementia #DementiaRisk