Insights into retinal disease and non-tubulin glutamylation from a RPGR-TTLL5 complex structure. New study by James H. Park, Richard J.Y. Liu, Xun Sun, Antonina Roll-Mecak (National Institute of Neurological Disorders and Stroke) and colleagues: rupress.org/jcb/article/...

#Cilia #StructuralBiology

Now THIS one was quite the journey. I'm beyond happy to see this work out in the world 🥹

Huge congrats to @computingcaitie.bsky.social and also to @hugovdhoek.bsky.social and everyone else involved ♥️

with @centriolelab.bsky.social @stearnslab.bsky.social @cellarchlab.com

#Cilia #CryoET #TeamTomo

#cilia #cryoet #proteomics

Really cool study using CLEM to determine the intermediates steps of intracellular ciliogenesis😉

www.biorxiv.org/content/10.6...

#cilia #CLEM

A full session of rising international talent across 6 hot talks from ciliary gates to tips, centriolar satellites to centrosomes, signaling & centriole remodelling- we'll cover it all!!

#cilia #centrosomes #centrioles #CellBiology #StructuralBiology #CentriolarSatellites #Hedgehog #Kinesins
2/2

Another #cilia kinesin motor: kinesin-8 KIF19A localizes to ciliary tips of Drosophila mechanosensory neurons

In 2012, Hirokawa lab showed KIF19A regulated ciliary length & localized to ciliary tips in mice; knockouts had hydrocephalus and female infertility phenotypes (PMID 23168168). #ciliopathy

Shan Wang et al. @tsinghuauniversity.bsky.social reveal how nanoscale polarity emerges at mechanosensory ciliary tips. A #kinesin-8 motor, Kif19A, drives localized transport that is stabilized by region-specific receptor binding, counteracting rapid diffusion. rupress.org/jcb/article/...

#Cilia

Park, Liu, Sun, Roll-Mecak et al. present the crystal structure of an RPGR–TTLL5 co-complex, which reveals TTLL recognition paradigms for non-tubulin substrates and sheds light on disease mechanism for retinal dystrophies caused by TTLL5 and RPGR mutations. rupress.org/jcb/article/...

#Cilia

Park, Liu, Sun, Roll-Mecak et al. present the crystal structure of an RPGR–TTLL5 co-complex, which reveals TTLL recognition paradigms for non-tubulin substrates and sheds light on disease mechanism for retinal dystrophies caused by TTLL5 and RPGR mutations. rupress.org/jcb/article/...

#Cilia

#aiimages #iconoplasm #AIArt #AIArtist #AIArtwork #GenArt #DigitalArt #AIArtGallery #AIGeneratedArt #AIArtCommunity #monster #horrorart #creativeai #synthart #lovecraft #tentacles #cilia

Silly 8

Congratulations to Sindija Šmite for obtaining the funding from the Grant Agency of the @charlesuni.cuni.cz, & her co-worker Hanka Hajšmanová 🤩 🎉 Looking forward to the new discoveries in the amazing world of cilia biology in neuronal cell behavior #cilia #BardetBiedlSyndrome @imgprague.bsky.social

Home - 14TH ANNUAL MEETING ON CILIA, FLAGELLA AND CENTROSOMES 14TH ANNUAL MEETING ON CILIA, FLAGELLA AND CENTROSOMES

Registrations for our 2026 meeting are now open !
Our 14th meeting on #cilia, #flagella, #centrosome and #ciliopathies to be held September 21-23, 2026, Aussois, France. Visit our website below for program, information, and registration...

www.cfc2026.conferences-pasteur.org/home

📣 The Cilia2027 Best Image Competition is open! 🧬✨

🏆 1st Prize: Cover of the program & website + FREE registration to Cilia2027
🥈🥉 2nd & 3rd: Featured in the event screensaver + website

Submit your best cilia visuals: forms.gle/jUC2tnsa5Cs8...

#Cilia2027 #Microscopy #SciArt #Cilia

3/3 All these effects are dependent on levels of #glycylation in comparison to #glutamylation on #microtubules. Thus, #glycylation acts as a central regulatory element of #TubulinCode orchestrating #cilia trafficking and function. Funded by @India_Alliance @serbonline @ANRFIndia

1/3 Lab #Preprint alert…A cool study led by @MullickSan22454 in collab with @ms_chirps lab showing how tubulin glycylation regulates ciliary motors and MAPs in vitro. @biorxiv_biochem. #glycylation #tubulinPTMs #cilia #Intraflagellartransport. Read more biorxiv.org/content/10.648…

Üç ay sonra Maduro’dan ilk sözler; “Kararlıyız" - OLAY NET Üç aydır New York'ta tutuklu bulunan eski Venezuela lideri Nicolas Maduro ile eşi Cilia Flores, kamuoyuna ilk kez seslendi.

Üç ay sonra Maduro’dan ilk sözler; “Kararlıyız” olaynet.net/2026/03/uc-a... #cilia flores açıklama #maduro abd operasyonu #new york mdc cezaevi #nicolas maduro tutuklama #venezuela güncel haber #Dünya

#Cilia are beautiful!

That's it, that's the tweet.

Oh, and Happy #FluorescenceFriday 🔬

Insights into the zebrafish left–right organizer's centrosomes and cilia via volume electron microscopy Summary: An electron microscopy-based reconstruction of all cilia and centrosomes within an intact left–right organizer reveals unexpected structural diversity at organ scale.

Hehnly lab recently graduated PhD student, Favour Ononiwu's paper using #vEM on the #zebrafish Left Right Organizer is live! Check out all the cool #centrosomes and #cilia: journals.biologists.com/bio/article/...

Come and join us in the beautiful #Savoie mountains to discuss the latest research on #cilia!

Hello everyone, we had a great meeting yesterday @institutimagine.bsky.social , thanks again to all the speakers for their very interesting talks on primary and motile #cilia #flagella #ciliopathies! Next one is organized by Caroline Brun, Marine Laporte, Véronique Morel in Aussois in September!

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome.

Congratulations to Lucile Boutaud, Sophie Thomas and colleagues @institutimagine.bsky.social ! #cilia #ciliopathies

onlinelibrary.wiley.com/doi/10.1111/...

Our next afternoon meeting is organized by @alexbnmrh.bsky.social on Wednesday March 18 @institutimagine.bsky.social ! Happy to see you soon there...
#cilia #ciliopathies #flagella

Zooplankton larvae shoot up in the water column when exposed to high pressure.

Mediated by special pressure-sensory photoreceptors.

From our paper on the mechanism of barotaxis.

https://elifesciences.org/articles/94306
#cilia #plankton #neuroscience

📣Short perspective article in #Cytoskeleton introducing the Czech 🇨🇿 #Cilia #research community (from now on officially termed 🪧CiliaNet CZ 💪).
👇
onlinelibrary.wiley.com/doi/10.1002/...

#cilia peeps 🤯

PoL – Physics of Life | Team | PoL Groups | Benjamin Friedrich Physics of Life: Discover new paradigms for understanding life and deepen our knowledge of living biological matter

Looking for a theory partner for an #HFSP project? #morphogenesis in cells and tissues, #chemotaxis, #cilia? Feel free to reach out! Deadline for letters of intent 26.03.2026.
physics-of-life.tu-dresden.de/team/pol-gro...

An inducible multiciliated cell line resolves proteome dynamics and identifies CDK7 as a conserved regulator. New study from Camille Boutin @camboutin.bsky.social, Laurent Kodjabachian @ibdm.bsky.social @univ-amu.fr and colleagues: rupress.org/jcb/article/...

#Cilia #Technology #Development

🧪 🧫 Photoreceptors depend on exquisitely organised cilia, with disruptions in microtubule regulation compromising retinal health. Beyond providing molecular diagnoses to affected families, this work deepens our understanding of ciliary biology, and highlights why fundamental research matters.
#Cilia

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization Pathogenic Bordetella bacteria use protein adhesins to infect the ciliated respiratory epithelia of vertebrate hosts. In this work, we show that the filamentous hemagglutinin FhaB adhesin of Bordetell...

SPOILER: Bordetella sticks to #cilia

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization | Science www.science.org/doi/10.1126/...

The figure shows staining of mouse embryos with X-gal to highlight Ttc21b in whole-mount embryos (panels A-D,H) or after sectioning (panels E-G,I-N). Boxed areas in panel E are shown magnified in panels F and G, boxed areas in panels I and L are shown magnified in panels J and M. Arrows indicate specific areas of lacZ expression.

Rebekah Niewoehner, Rolf Stottmann & co found that pathogenic Ttc21b variants, the primary #cilia gene, contribute to primary #microcephaly, with homozygous #mouse mutants showing severe #microcephaly due to impaired neural progenitor proliferation and differentiation.

Read doi.org/10.1242/dmm....