Activated #Notch1 signaling drives #BMP2-induced endochondral #ossification in #MSCs by suppressing #Sox9-driven chondrogenesis and enhancing #VEGFA-mediated #angiogenesis, highlighting Notch1 as a target to improve #CartilageRegeneration.

#OpenAccess: doi.org/10.1016/j.ge...

This study reveals hybrid #extracellularvesicles (EV) as unrecognized osteoarthritis (OA) pathogenic drivers, linking EV-mediated irreversible mitochondria damage to chondrocyte aging, and opens a new avenue for OA treatment.
doi.org/10.1016/j.xi...
#osteoarthritis #Metabolism #cartilageregeneration

Inhibiting a master regulator of aging regenerates joint cartilage in mice – BioNews Central An injection that blocks a protein linked to aging reverses cartilage loss in the knee joints of aged mice and prevents arthritis after injury, while an oral version is already undergoing clinical trials for age-related muscle weakness. ...

An injection that blocks a protein linked to #aging reverses #CartilageLoss in the #KneeJoints of aged mice and prevents #arthritis after injury, while an oral version is already undergoing clinical trials for #AgeRelatedMuscleWeakness.
#Osteoarthritis #CartilageRegeneration #CartilageRepair

BMP2 up-regulates the expression of Notch receptors & ligands in MSCs, mediating BMP2-induced endochondral ossification by promoting RBPjk-mediated Sox9 inactivation & VEGFA expression. #CartilageRegeneration #medsky
#MostRead

#OpenAccess:
www.sciencedirect.com/science/arti...

Notch1 signaling regulates Sox9 and VEGFA expression and governs BMP2-induced endochondral ossification of mesenchymal stem cells

In vitro & in vivo differentiation models showed that BMP2 up-regulates the expression of Notch receptors & ligands in MSCs, mediating BMP2-induced endochondral ossification by promoting RBPjk-mediated Sox9 inactivation & VEGFA expression. #CartilageRegeneration #medsky

#OpenAccess: buff.ly/2dcAJmL

Diana Hammerstone ’20 earns prestigious graduate research fellowship It was an honor when she first learned that her advisor was nominating her for the Koerner Family Foundation (KFF) Fellows program, but Diana Hammerstone ’20 is a busy fifth-year materials science and...

Congrats to Diana Hammerstone ’20 for being elected the Koerner Family Foundation's Fellow. Nom'd by @thechowlab.bsky.social, the award supports her research- #polymer based scaffold development used for #tissueengineering w/ potential to aid in #cartilageregeneration: shorturl.at/ZE5j4