Scientists show #lncRNA AC004854.2 drives #ColorectalCancer by disrupting the PUF60–FUBP1 complex to boost #cMYC transcription; forming a SOX4/AC004854.2/PUF60/c-MYC axis that promotes #tumor growth, attenuated by c-MYC inhibition.
#OpenAccess: doi.org/10.1016/j.ge...
First opponent Prof Francesca Sacco started the discussion on #hematopoietic differentiation @francisacco.bsky.social
#phddefense #PhDLife #CMYC
#SMYD3 methylates #cMYC at K158/K163 residues to sustain stemness, self-renewal & #metastasis in #ColorectalCancer stem cells; its inhibition disrupts #clonogenicity and tumorigenicity, positioning the SMYD3/c-MYC axis as a therapeutic target in #CRC.
#STTT: doi.org/10.1038/s413...
#SMYD3 methylates #cMyc to sustain #ColorectalCancer stem cell self‑renewal and #metastasis; inhibition of SMYD3 reduces #clonogenicity, #tumorigenicity, and dissemination, highlighting the SMYD3/c‑MYC axis as a therapeutic target for CRC.
#CoverPage #STTT: doi.org/10.1038/s413...
The lysine methyltransferase #SMYD3 is identified as a key regulator of #ColorectalCancer #StemCell. Its inhibition disrupts #cMYC methylation and reduces #Tumor growth and #Metastasis, highlighting SMYD3 as a promising therapeutic target. #medsky
#STTT: doi.org/10.1038/s413...
Scientists identify a #TNBC-upregulated #lncRNA, CDKN2B-AS1, encoding a 66-amino-acid peptide (66CTG) that promotes #tumor growth by stabilizing #cMyc and enhancing #CyclinD1, revealing a novel 66CTG–FBW7α–c-Myc regulatory axis. #medsky
#OpenAccess #STTT: doi.org/10.1038/s413...
This work was a major collaborative effort across Zurich 🇨🇭 and Seattle 🇺🇸.
We’re excited about what it means for the future of TB immunotherapy—and for understanding immune evasion across diseases. #TB #cMyc #Macrophages #HostDirectedTherapy
Muy interesante el informe #Cientificas_en_Cifras_2025 del #MICIU, con conclusiones parecidas al informe del @csic.es
#CMyC.
Sobre todo (y una vez más), el típico gráfico en tijera no se corrige, por si solo, con el tiempo: gráfica comparativa de la última década.
Enhorabuena para el @csic.es y su Comisión de Mujeres y Ciencia #CMyC!! Particularmente a su presidenta @eloisadelpino.bsky.social y vicepresidenta #Carmen_Mayoral.
👏👏👏
