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#
Hashtag
#SMYD3
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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
1 month ago
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#SMYD3 methylates #cMYC at K158/K163 residues to sustain stemness, self-renewal & #metastasis in #ColorectalCancer stem cells; its inhibition disrupts #clonogenicity and tumorigenicity, positioning the SMYD3/c-MYC axis as a therapeutic target in #CRC.

#STTT: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
3 months ago
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#SMYD3 methylates #cMyc to sustain #ColorectalCancer stem cell self‑renewal and #metastasis; inhibition of SMYD3 reduces #clonogenicity, #tumorigenicity, and dissemination, highlighting the SMYD3/c‑MYC axis as a therapeutic target for CRC.

#CoverPage #STTT: doi.org/10.1038/s413...

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Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
@sigtrans-sttt.bsky.social
5 months ago
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The lysine methyltransferase #SMYD3 is identified as a key regulator of #ColorectalCancer #StemCell. Its inhibition disrupts #cMYC methylation and reduces #Tumor growth and #Metastasis, highlighting SMYD3 as a promising therapeutic target. #medsky

#STTT: doi.org/10.1038/s413...

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