FEBS Press Native holdup allows the quantitative determination of affinities between full-length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which ca...

Excited to share our new paper on DNA-native holdup!
An updated method to measure DNA–protein binding affinities at high throughput - even for full-length transcription factors. @teamgogl.bsky.social

#TranscriptionFactors #GATA1 #ProteinDNA #Biophysics #Genomics #MolecularBiology #OpenScience

New study from @pennmedicine.bsky.social! scRNA-seq of isogenic #iPSC reveal novel individual and cooperative #hematopoietic effects of #trisomy21 and #GATA1. #myelopoiesis #Downsyndrome ow.ly/fpHC50Wrrtm

@childrensphila.bsky.social @isscr.org @gairdnerawards.bsky.social @sickkidsvs.bsky.social