🚨 A new episode is out!
Dr. Margaret "Peggy" Goodell from @bcmhouston.bsky.social talks about her seminal discovery of a side population of HSCs, as well as her work on #DNMT3A mutation and clonal #hematopoiesis of indeterminate potential. 🩸
🎧 bit.ly/3YJKixl
For older males who are frequent #blood donors, the frequency of #ClonalHematopoiesis was not found to differ from that seen in sporadic blood donors, but their #hematopoietic stem cells did show a distinct pattern of mutations in #DNMT3A: ow.ly/xaXZ50VM8WS
#HemeSky
Augment del risc de càncer després d’una sola mutació a #DNMT3A que silencia la #p53, la principal peça que resguarda el genoma.
La recerca ha estat feta a Australia, als centres: ONJCRI i WEHI,
🧬 Researchers at ONJCRI and WEHI have determined that a specific DNA mutation in DNMT3A can weaken a major tumour-suppression pathway in blood stem cells.
Read more about the research which was published in @emboreports.org today: ow.ly/xLAp50VK6r5
#DNMT3A #AML
Excited to share the @goodell-lab.bsky.social News&Views on 3 exciting studies by Vassiliou Lab, Chan Lab, and @trowbridgelab.bsky.social in @nature.com and @natcomms.nature.com, showing that #DNMT3A mutant (major driver of Clonal Hematopoiesis) blood cells depend on mitochondrial respiration.
Clonal hematopoiesis drives femoral atherosclerosis in middle-aged adults 🔬❤️📊 www.news-medical.net/news/2024090... #CardiovascularResearch #Atherosclerosis #ClonalHematopoiesis #GeneticMutations #DNMT3A #TET2 #Heart #MiddleAge #PreventiveMedicine #Health
