🩸🔍First question of the month!
Swipe to see the answer and its explanation.
#CMML #ChronicMyelomonocyticLeukemia #Hematology #MyeloidNeoplasms #ClonalHematopoiesis #CHIP #TET2 #SRSF2 #ASXL1 #BoneMarrow #Monocytosis #FlowCytometry #HematologicMalignancies #HemeEd #HemeHub #BloodCancer
🩸Facts about Chronic Myelomonocytic Leukemia:
Disease Biology & Pathogenesis
#CMML #MDS #MPN #Hematology #HematologicMalignancies #ClonalHematopoiesis #CHIP #TET2 #SRSF2 #ASXL1 #MyeloidNeoplasms #MedEd #HemeEd #HemeHub #BloodCancer #MyeloidDisorders #ClinicalHematology
Looking forward to the Germline Predisposition FSW at #ASH24… (check out summary at link below!). For those attending - make sure you stay to hear Sean Harrop present our work on germline #TET2 variants and an emerging novel syndrome..
#hemesky #hemepath #hematology
youtu.be/UEKszF06k2Y
#TET2 germline variants & kidney disease ft. @LiangXiujie, @Hongbo919Liu, Hailong Hu, Eunji Ha, Jianfu Zhou, @AminAbedini1990, @andrea_26sn, @KonstantinKltz & @ksusztak.bsky.social (@PennKidney/ @penngenetics.bsky.social) @naturecomms.bsky.social www.nature.com/articles/s41...
8) "What we hope we can get from this is a silver bullet to #selectively get rid of just #cancer #cells, by targeting this specific pathway," says He.
In #older #people, these #TET2 #mutations have also been linked with a higher risk of #inflammatory #conditions
6) Building on previous work looking at how DNA and RNA combine to build proteins through gene expression, the researchers used a variety of advanced gene editing and analysis techniques in the lab to look at the #relationship between #TET2 and #RNA methylation.
3) If that control is lost, the biological production line can start to go haywire.
"If you have a #TET2 #mutation, you reopen this #growth #pathway that could eventually lead to #cancer – especially in the #blood and #brain, because this pathway looks to be most important in blood and brain
2) Early in life, #TET2 helps developing cells by making chromatin more accessible, supporting the expression of genes so stem cells can become other types of cells.
In adults, TET2 tightens control by limiting MBD6.
Clonal hematopoiesis drives femoral atherosclerosis in middle-aged adults 🔬❤️📊 www.news-medical.net/news/2024090... #CardiovascularResearch #Atherosclerosis #ClonalHematopoiesis #GeneticMutations #DNMT3A #TET2 #Heart #MiddleAge #PreventiveMedicine #Health
