Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking‐Induced Lung Tumorigenesis Schematic illustration of the roles of CIP2A and RING1 in lung tumorigenesis Accumulation of DNMT1 due to NNK exposure leads to a reduction in RING1 mRNA levels. Decreased RING1 results in an accumul...

#Article in #MedComm
This article finds that Ring Finger Protein 1 is a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking-Induced Lung Tumorigenesis doi.org/10.1002/mco2...

#CIP2A #RING1 #DNMT1

Disruption of the epigenetic enzyme #DNMT1 has particularly severe biological consequences. DNMT1 maintains DNA methylation, playing critical roles in gene regulation, genomic imprinting, transposable element silencing, cell fate, and more.

Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation Beyond its role as RNA m6A writer, METTL3-METTL14 can mediate 5mC deposition on DNA by recruiting the DNA methyltransferase DNMT1 to chromatin. The two marks co-orchestrate the expression of key genes...

Linking RNA modifications to DNMT1 function on gene bodies

Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation | Cell

#Epigenetics #DNAme #Development #DNMT1 #RNA

www.cell.com/cell/abstrac...

Really nice study ! Looking forward to having a deep look at the data. Congrats. #DNMT1 #DNMT3A

RAD51 protects abasic sites to prevent replication fork breakage Hanthi et al. found that RAD51 recognizes and binds to abasic sites. Together with BRCA2, RAD51 prevents the accumulation of abasic site-induced replicative DNA gaps (caused by DNA methylation, oxidat...

Excited to share my first co-first author paper! We uncovered a conserved role for RAD51/BRCA2 in protecting abasic sites at replication forks from MRE11 cleavage.
#ssDNA gaps, #DNMT1, #POLθ, #Cryo-EM of #RAD51 bound to AP sites, and much more! Check it out!