Skiteam #CIP2A demonstrated admirable attitude and performance on yesterday´s training session. Some of the bravest with training background from the past years already approached the 3 km track with up and downhills. #lifeinfinland @westermarcklab.bsky.social #lifeoutsidethelab

Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking‐Induced Lung Tumorigenesis Schematic illustration of the roles of CIP2A and RING1 in lung tumorigenesis Accumulation of DNMT1 due to NNK exposure leads to a reduction in RING1 mRNA levels. Decreased RING1 results in an accumul...

#Article in #MedComm
This article finds that Ring Finger Protein 1 is a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking-Induced Lung Tumorigenesis doi.org/10.1002/mco2...

#CIP2A #RING1 #DNMT1

Emerging roles of the cancerous inhibitor of protein phosphatase 2A (CIP2A) in ovarian cancer Scientific Reports - Emerging roles of the cancerous inhibitor of protein phosphatase 2A (CIP2A) in ovarian cancer

Very nice bioinformatics analysis of the role of #CIP2A in ovarian cancer by @karteris.bsky.social
rdcu.be/exid3

A new model figure why #CIP2A is such a potent therapy target for #TNBC and other homologous recombination deficient cancers. Two punch effect by hitting one protein; both DNA repair and #PP2A regulated oncogenicity/proliferation inhibited by CIP2A inhibition.