New preprint from us.
The study led by Mukund Sharma demonstrates how #PP2A mediated dephosphorylation of serine 166 of LSD1 functions as a phosphorylation switch between gene repression and activation by LSD1 and how this shapes tumor microenvironment.
www.biorxiv.org/content/10.1...
A new model figure why #CIP2A is such a potent therapy target for #TNBC and other homologous recombination deficient cancers. Two punch effect by hitting one protein; both DNA repair and #PP2A regulated oncogenicity/proliferation inhibited by CIP2A inhibition.
Oh boy, #PP2A again contaminating #phosphatase research. First it was physiological PP2A binding that explained the S/T PPase activity of Eye, now it is a real contamination of PHLPP1/2 protein preps. Important work that forces to entirely rethink the past literature on PHLPPs.
New #PP2A research tools in @addgene.bsky.social by us. PME-1 lentivirus overexpression vectors for wild type and methylesterase and PP2Ac binding mutants www.addgene.org/browse/artic... Please check also our entire collection including various CIP2A tools. Enjoy www.addgene.org/Jukka_Wester...
