RAD51 forms filaments that search for a matching DNA template to repair the break

Moss BRCA2 can also recruit RAD51, a recombinase protein that forms filaments on DNA to repair double-strand breaks during homologous recombination.
#RAD51 #DNARepair

Plot twist: homologous recombination promotes cancer development The prevailing view considers homologous recombination to be a tumour-suppressing mechanism. However, a re-analysis of data and concepts published in the journal Oncogene concludes that, in fact, homo...

In a review article published in the Journal #Oncogene, Bernard Lopez proposes that #RAD51 -mediated homologous recombination is a Pro-tumour driver pathway, contradicting the generally accepted dogma
institutcochin.fr/en/news/plot...
@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social

RAD51 biomarker could complement next-generation sequencing in personalizing prostate cancer treatment

🗞️ Published in @cp-cellrepmed.bsky.social: A VHIO-led study reveals that the #RAD51 biomarker could complement next-generation sequencing to personalize #prostatecancer treatment.

➡️ linke.to/RAD51VHIO

RAD51 protects abasic sites to prevent replication fork breakage Hanthi et al. found that RAD51 recognizes and binds to abasic sites. Together with BRCA2, RAD51 prevents the accumulation of abasic site-induced replicative DNA gaps (caused by DNA methylation, oxidat...

Excited to share my first co-first author paper! We uncovered a conserved role for RAD51/BRCA2 in protecting abasic sites at replication forks from MRE11 cleavage.
#ssDNA gaps, #DNMT1, #POLθ, #Cryo-EM of #RAD51 bound to AP sites, and much more! Check it out!

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Many alterations in HRR related pathways may not cause functional HRD. After DNA damage, #RAD51 forms foci to repair the DNA by homologous recombination. The loss of RAD51 foci is an indicator of the cells current inability to repair DNA by HRR.