Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology - Molecular Neurodegeneration The autophagy-lysosomal pathway is crucial for maintaining homeostasis and survival of neurons, hence defects in this system have been associated with neurodegeneration, including Parkinson's disease ...

Recombinant #cathepsins B and L promote α-synuclein clearance and restore #lysosomal function in human and murine models with α-synuclein pathology

Denise Balta, Anish Varghese, Susy Prieto Huarcaya..Friederike Zunke @fau.de #Parkinsons

molecularneurodegeneration.biomedcentral.com/articles/10....

Even more ironically, the #Furin site gets in the way of lab propagation. We have grown #SARS-CoV-2 on Vero cells and it naturally evolved to lose this cleavage site. Namely, the virus adapted to utilize another class of Enzymes called #Cathepsins, which are present in endosomes of Vero cells. 11/15