This image depicts a nematode with fluorescently labeled bacteria in its intestine (left), illustrating microbial metabolic input. On the right, fluorescently marked epidermal lysosomes (top), intestinal lysosomes (middle), and lipid droplets (bottom) highlight the organelles engaged in lysosome-dependent lipid degradation. Together, the image visualizes a microbiota–lysosome axis through which bacterial tryptophan metabolism reprograms host lipid homeostasis. Image Credit: Kenan Zhang

Microbial metabolites can influence host physiology. This study shows that #microbial production of #indole from #bacterial #tryptophan catabolism enhances #lysosomal acidification & lipase activity in nematodes & mammalian hepatocytes @plosbiology.org 🧪 plos.io/3ZZAsaI

This image depicts a nematode with fluorescently labeled bacteria in its intestine (left), illustrating microbial metabolic input. On the right, fluorescently marked epidermal lysosomes (top), intestinal lysosomes (middle), and lipid droplets (bottom) highlight the organelles engaged in lysosome-dependent lipid degradation. Together, the image visualizes a microbiota–lysosome axis through which bacterial tryptophan metabolism reprograms host lipid homeostasis. Image Credit: Kenan Zhang

Microbial metabolites can influence host physiology. This study shows that #microbial production of #indole from #bacterial #tryptophan catabolism enhances #lysosomal acidification & lipase activity in nematodes & mammalian hepatocytes @plosbiology.org 🧪 plos.io/3ZZAsaI

This image depicts a nematode with fluorescently labeled bacteria in its intestine (left), illustrating microbial metabolic input. On the right, fluorescently marked epidermal lysosomes (top), intestinal lysosomes (middle), and lipid droplets (bottom) highlight the organelles engaged in lysosome-dependent lipid degradation. Together, the image visualizes a microbiota–lysosome axis through which bacterial tryptophan metabolism reprograms host lipid homeostasis. Image Credit: Kenan Zhang

Microbial metabolites can influence host physiology. This study shows that #microbial production of #indole from #bacterial #tryptophan catabolism enhances #lysosomal acidification & lipase activity in nematodes & mammalian hepatocytes @plosbiology.org 🧪 plos.io/3ZZAsaI

Examination of effects of Roux-en-Y #gastric #bypass surgery (an effective treatment option for #obesity) on #indole metabolite profile in the gut reports that
these metabolites do not support #metabolic benefits of RYGB, but may contribute to post-surgery #gut #inflammation
doi.org/10.14814/phy...

Advances in the synthesis of indolizines and their π-expanded analogues: update 2016–2024 Indolizine (pyrrolo[1,2-a]pyridine) is an isomer of indole. The diversity of synthetic approaches leading to the indolizine skeleton is unrivalled, compared to many other heterocycles of this size. In...

🔊Be sure to check out the review by Daniel T. Gryko et al. from Institute of Organic Chemistry of the Polish Academy of Sciences

👉Advances in the synthesis of #indolizines and their π-expanded analogues: update 2016–2024
#indole #Chemsky #Organic #OCFreview

🔗https://doi.org/10.1039/D4QO02082K

Gut microbes have an unexpected link to anxiety Discover how groundbreaking research reveals that gut microbes and probiotics could revolutionize anxiety relief and mental health care.

Time for #indole supplementation www.earth.com/news/gut-mic...

This is a smart paper which investigates a mechanism for which the #GutMicrobiota can influence adult #neurogenesis via #typtophan metabolism to #indole 🦠http://pnas.org/content/118/27/e2021091118 @PNASNews