Lewy body co‐pathology in Alzheimer's disease and primary age‐related tauopathy contributes to differential neuropathological, cognitive, and brain atrophy patterns INTRODUCTION Alzheimer's disease (AD) co-pathology with Lewy bodies (LB) is frequent and influences clinical manifestations and outcomes. Its significance in primary age-related tauopathy (PART) is ...

Therefore, by studying #α-synuclein #copathology in #PART we were able to “capture” its cognitive toxic effect independently of #amyloid pathology & we had already predicted this would be a key factor for clinical trial design.

More at: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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From the many groundbreaking advances at #ADPD2026 I highlight the following presentation tackling the relevance of #copathology in #Alzheimer:

→Using #gantenerumab trial data the Roche team did a retrospective analysis of CSF samples assessing α-synuclein co-pathology

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