Graphical abstract of the Molecular and Cellular Proteomics paper, Proteomic analysis of Hsp90β-selective inhibitors against triple-negative breast cancer (TNBC) to gain a mechanistic insight.

From #asbmbMCP | In this article, authors examined mechanisms of action of two Hsp90β inhibitors against triple-negative #breastcancer, or TNBC, using a bottom-up liquid chromatography tandem mass spectrometry proteomics approach: www.mcponline.org/ar....
#DNARepair #Proteomics

Graphical abstract of the Molecular and Cellular Proteomics paper, Proteomic analysis of Hsp90β-selective inhibitors against triple-negative breast cancer (TNBC) to gain a mechanistic insight.

From #asbmbMCP | In this article, authors examined mechanisms of action of two Hsp90β inhibitors against triple-negative #breastcancer, or TNBC, using a bottom-up liquid chromatography tandem mass spectrometry proteomics approach: ow.ly/uycU50WNPnK.
#DNARepair #Proteomics

A graphical abstract of the MCP paper, "Isolation of Proteins on Chromatin Reveals Signaling Pathway–Dependent Alterations in the DNA-Bound Proteome." Isolation of protein on chromatin (iPOC) specifically enriches DNA binding proteins. Researchers tested and selected optimal conditions for critical steps in iPOC workflow. iPOC was used to characterize the chromatome downstream of PI3K/AKT/mTOR pathway. PI3K, AKT, and mTOR regulate the epigenome by modulating the DNA-binding status of SUZ12.

Researchers developed a #chromatin isolation technique that preserves protein–DNA interactions. They then applied mass spectrometry & bioinformatics analysis to examine how signaling pathways alter the chromatin-bound proteome.
➡️Here's what they found: ow.ly/3wrf50WK0vA. #asbmbMCP #MassSpec

RA patient blood reveals joint innerworkings Researchers in the Netherlands use mass spectrometry to compare the proteome of plasma and synovial fluid in rheumatoid arthritis patients and find a correlation. Read more about this recent paper in Molecular & Cellular Proteomics.

In a recent study published in MCP, researchers at Leiden University Medical Center & Utrecht University used proteomics to show that proteins, including antibodies & autoantibodies, pass from blood into joint fluid without bias in RA patients.
ow.ly/pj8t50WvBzh #RheumatoidArthritis #asbmbMCP

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A proteomic heatmap becomes the path through which parasite Fasciola hepatica reveals its migration across the host. This pathway captures dynamic changes in protein expression that drive invasion, adaptation, and survival. Image credit: Marta López-García, PhD candidate, IRNASA-CSIC, Salamanca, Spain.

A proteomic heatmap becomes the path through which parasite Fasciola hepatica reveals its migration across the host. The pathway captures dynamic changes in protein expression that drive invasion, adaptation & survival.
ow.ly/jr3b50WkGgo
Marta López-García
@asbmbjournals.bsky.social #asbmbMCP