Figure 1. Experimental set-up. A schematic overview of the multi-omics approach.

New JLR press| Longitudinal analysis of lipid changes in the sciatic nerve caused by overexpression of PMP22 in murine models of CMT1A.
Learn more:
www.jlr.org/article/...
#asbmbJLR

Early lipid changes drive retinal degeneration in Zellweger spectrum disorder Lipid profiling in a rare disease mouse model reveals metabolic shifts and inflammation in the retinal pigment epithelium — offering promising biomarker leads to combat blindness.

#MolecularBiologyMonday | Lipid profiling in a rare disease mouse model reveals metabolic shifts and inflammation in the retinal pigment epithelium — offering promising biomarker leads to combat #blindness.

Learn more: ow.ly/YWQp50X0ysk.
#asbmbJLR #RareDisease #Zellwegerspectrumdisorder

Find out how lipids and sugars in the cell nucleus are involved in signaling and gene expression and how these pathways could be targeted to identify therapeutics for diseases like #cancer ⏯️: youtu.be/KO_Z9rJmN2M?....
➡️More info: ow.ly/fHs050WELyB
#ASBMBBreakthroughs #asbmbJLR #cancersky #sciencesky

Find out how lipids and sugars in the cell nucleus are involved in signaling and gene expression and how these pathways could be targeted to identify therapeutics for diseases like #cancer ⏯️: youtu.be/KO_Z9rJmN2M?....
➡️More info: ow.ly/fHs050WELyB
#ASBMBBreakthroughs #asbmbJLR #cancersky #sciencesky

Omega-3 fats linked to healthy aging and improved heart metabolism Scientists from the University of Iowa find that a diet high in polyunsaturated fatty acids from fish oil increases cardiac triglyceride uptake and improves insulin sensitivity. Read more about this r...

🧪Scientists from the University of Iowa find that a diet high in polyunsaturated fatty acids from fish oil increases cardiac triglyceride uptake & improves insulin sensitivity.
Read more about this recent JLR study: ow.ly/OQkb50Wz39j.
#ASBMBJournals #asbmbJLR #NutritionScience #CardiacHealth #SciSky

Have you recently published a paper in one of ASBMB's journals? Let us know by replying to this post with the link to your paper or tagging @asbmbjournals.bsky.social. We'll add you to our new list so that colleagues can keep up with your work!
bsky.app/profile/did:...
#asbmbJBC #asbmbMCP #asbmbjlr

You can also note which journal using #asbmbJBC, #asbbmbMCP or #asbmbJLR. Thank you in advance for helping us amplifying researchers' work!

The graphical abstract showcases the two first authors of a paper in JLR, introducing a novel HPLC-based lysoplasmalogenase assay using fluorescent derivatisation. Image credits: Denise Kummer & Ilaria Dorigatti.

🧪Featured on JLR’s May 2025 cover: Denise Kummer & Ilaria Dorigatti present a novel HPLC-based assay to quantify lysoplasmalogen catabolism—key for neurodegenerative disease research.
📄Read: ow.ly/2Jy750Wf0fe.
📷Kummer & Dorigatti
#ASBMBJournals #asbmbJLR #Alzheimers #Parkinsons

🧪Featured on JLR’ May 2025 cover: Kummer & Dorigatti present a novel HPLC-based assay to quantify lysoplasmalogen catabolism—key for neurodegenerative disease research.
📄Read: ow.ly/2Jy750Wf0fe.
📷Kummer & Dorigatti
#ASBMBJournals #asbmbJLR #Alzheimers #Parkinson

The conserved Mg2+-dependent phosphatidic acid phosphatase, as depicted by the predicted structure of its catalytic core (N-LIP domain, bronze; HAD-like domain, cyan, and amphipathic helix, magenta), catalyzes the dephosphorylation of phosphatidic acid to produce diacylglycerol, a key step in lipid metabolism. Yeast Pah1 and human lipin 1 forms of the enzyme are targeted for inhibition at the catalytic core by the antidepressant drug sertraline.

The Jan. cover of the Journal of Lipid Research highlights Stukey et al.'s paper, "The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 & human lipin 1 phosphatidic acid phosphatases."
➡️Access it here to learn about researchers' findings: ow.ly/536Z50UUmYs.
#ASBMBJournals #asbmbJLR