Figure 1. Subunit composition and ultrastructure of the canonical 26S proteasome.

New in JBC press| Plasticity in the structure and assembly of proteasomes.
Lean more:
www.jbc.org/article/...
#asbmbJBC

Figure 2. G-protein signalling mechanisms of Albumin-S1P, FTY-720 and ApoM-HDL-S1P

New in JBC press| Apolipoprotein M: Structural Insights, Functional Roles and Therapeutic Approaches in Vascular Disease.
Learn more:
www.jbc.org/article/...
#asbmbJBC

Ben Garcia stands in front of a bookcase lined with past printed issues of the Journal of Biological Chemistry, which have green covers and gold lettering. He is holding one of the journals open to his 2007 article "Organismal Differences in Post-translational Modifications in Histones H3 and H4."

Full circle moment!

While visiting ASBMB for a Maximizing Access Committee meeting, @garcialabms.bsky.social spotted one of his early JBC papers.
www.jbc.org/article/S002...

Do you remember the thrill of your early publications? Share below!
@asbmbjournals.bsky.social #asbmbJBC #TeamMassSpec

Structural basis of a distinct α-synuclein strain that promotes tau inclusion in neurons Amyloidoses are predominantly associated with the accumulation of persistent aggregates of a particular protein. For example, the protein α-synuclein characteristically aggregates in Parkinson's disea...

🧠 On #WorldAlzheimersDay, we’re highlighting research from #ASBMBJournals.

In JBC, researchers report that a recently established α-syn fibril strain markedly prompts the co-aggregation of tau protein in both neuronal cells and in vitro settings: ow.ly/8AiI50WZWWw.
#Tao #asbmbJBC #Alzheimers

Glow-based assay sheds light on disease-causing mutations University of Michigan researchers create a way to screen protein structure changes caused by mutations that may lead to new rare disease therapeutics.

There are several methods to identify protein structure changes. An #asbmbJBC paper via Michael Wang’s lab has added a new tool to the list that provides quantifiable results, suitable for high throughput screens when researchers just need to know if a protein structure is altered.
ow.ly/lTH450WQKUM

Computational tool helps scientists create novel bug sprays Rapid discovery of mosquito repellent compounds is enabled through a novel screening platform that combines both computational modeling and functional screening.

🦟 🌍On #WorldMosquitoDay: Vector-borne pathogens cause 17% of all infectious #diseases. In JBC, researchers described a screening platform to identify natural compounds that bind to #mosquito olfactory receptors and cause anosmia: ow.ly/Sr4650WJe7a.
#GlobalHealth #MedSky #ASBMBJournals #asbmbJBC

Brady has been an associate editor for the Journal of Biological Chemistry and co-chaired the 2025 ASBMB annual meeting. Her lab recently celebrated 10 years!
#ASBMBJournals #asbmbJBC #ASBMB25

Actives sites of lipase and endolysin domains contribute to the exogenous antimicrobial activity of ELP-E10.

🌱🥝 #MolecularBiologyMonday via #ASBMBjbc | Researchers at the @universityofotago.bsky.social a team of international scientists engineered a fusion protein that targets Psa, which causes kiwifruit canker & contributes to larger issues of food shortage.
ow.ly/MxET50WHWIh
#ASBMBJournals #biocontrol

Engineered fusion protein targets kiwifruit pathogen Synthetic protein selectively kills kiwifruit pathogen, offering a promising biocontrol strategy for agriculture. Read more about this recent JBC paper.

Thank you for highlighting! This research recently featured on ASBMB Today. Here's the link! ow.ly/MxET50WHWIh
#asbmbJBC #ASBMBJournals

Pathogen-derived enzyme engineered for antibiotic design Engineered variants of a bacterial enzyme developed at the University at Buffalo accept larger substrates, paving the way for new acinetobactin-based antimicrobials. Read more about this recent JBC pa...

#MolecularBiologyMonday | Engineered variants of a bacterial enzyme developed at the University at Buffalo accept larger substrates, paving the way for new acinetobactin-based antimicrobials.
➡️More about this JBC paper by Syed Fardin Ahmed & @amgulick-lab.bsky.social: ow.ly/gycb50WEjqE.
#asbmbJBC

Receptor antagonist reduces age-related bone loss in mice Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat osteoporosis. Read more about this recent JBC paper.

Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat #osteoporosis.
➡️ Read more about this recent JBC paper: ow.ly/OT3E50WB5uN.
#ASBMBJournals #asbmbJBC #OsteoporosisResearch #BoneHealth #AgingResearch

Receptor antagonist reduces age-related bone loss in mice Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat osteoporosis. Read more about this recent JBC paper.

Receptor antagonist reduces bone loss and promotes osteoblast activity in aging mice, highlighting its potential to treat #osteoporosis.
➡️ Read more about this recent JBC paper: ow.ly/OT3E50WB5uN.
#ASBMBJournals #asbmbJBC #OsteoporosisResearch #BoneHealth #AgingResearch

Have you recently published a paper in one of ASBMB's journals? Let us know by replying to this post with the link to your paper or tagging @asbmbjournals.bsky.social. We'll add you to our new list so that colleagues can keep up with your work!
bsky.app/profile/did:...
#asbmbJBC #asbmbMCP #asbmbjlr

You can also note which journal using #asbmbJBC, #asbbmbMCP or #asbmbJLR. Thank you in advance for helping us amplifying researchers' work!

This cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in amyloid regulation. Through its yarn motif, the image captures both the protective vigilance of CsgC and the transformation of CsgA from disorder to order.

🧶The June 2025 JBC cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in #amyloid regulation.
➡️Read the article by Balistreri et al. that inspired the cover: ow.ly/bmcE50WkG2O.
#ASBMBJournals #asbmbJBC @asbmb.bsky.social

This cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in amyloid regulation. Through its yarn motif, the image captures both the protective vigilance of CsgC and the transformation of CsgA from disorder to order.

🧶The June 2025 JBC cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in #amyloid regulation.
➡️Read the article by Balistreri et al. that inspired the cover: ow.ly/bmcE50WkG2O.
#ASBMBJournals #asbmbJBC

This cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in amyloid regulation. The gloved hands and knitting needles outside the cell symbolize the precise, stepwise construction of these extracellular fibers. Through its yarn motif, the image captures both the protective vigilance of CsgC and the transformation of CsgA from disorder to order.

🧶The June 2025 JBC cover art reimagines the bacterial periplasm as a tapestry of yarn, highlighting the crucial role of CsgC (magenta yarn) in #amyloid regulation.
➡️Read the article by Balistreri et al. that inspired the cover: ow.ly/bmcE50WkG2O.
#asbmbJBC @asbmbjournals.bsky.social

The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells The SEL1L-HRD1 complex is a critical component of the endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, essential for maintaining ER homeostasis and cellular function. While th...

New in JBC press: "Scientists' findings indicate that SEL1L is not required for ER homeostasis or the differentiation of male germ cells."
➡️Learn more: ow.ly/WPzG50Wk8HB.
#ASBMBJournals #asbmbJBC #endoplasmicreticulum

The cover features a lake as the background, with black and white zebrafish in the center, symbolizing melanin changes. The design draws on the Chinese "Tai Chi" symbol, representing cyclicality in traditional culture. Surrounding the center is the amino acid sequence of the MCH cyclic peptide, highlighting its regulatory role in this cycle. The outermost layer includes the reflections of the sun and moon, symbolizing the transition between sleep and wakefulness.

The cover of the May 2025 issue of JBC illustrates how the MCH cyclic peptide in zebrafish connects sleep pressure & melanin degradation, reflecting a cyclical process.
➡️Read the paper by Guo, Qingquan et al.: jbc.org/article/S002....
#SleepScience #asbmbJBC

Calcium channel linked to cancer drug resistance Researchers discover a protein associated with carboplatin-resistant retinoblastoma, suggesting this protein could be a promising therapeutic target. Read more about this recent Journal of Biological ...

Sooyun Kim & researchers at Seoul National University discovered a protein associated with carboplatin-resistant retinoblastoma, suggesting this protein could be a promising therapeutic target.
➡️Read more about this recent JBC paper: ow.ly/eX6B50W8CPb.
#ASBMBJournals #asbmbJBC

E-cigarettes drive irreversible lung damage via free radicals E-cigarettes are often thought to be safer because they lack many of the carcinogens found in tobacco cigarettes. However, scientists recently found that exposure to e-cigarette vapor can cause severe, irreversible lung damage.

“E-cigarette juice can have a nicotine concentration as high as 150 millimolar ... And we saw that (lung) toxicity occurs at micromolar levels (1000 times less). It’s just off the scale.”
—Jay L. Zweier of the Ohio State University
www.asbmb.org/asbmb-....
#ASBMBJournals #asbmbJBC