Spatial Lipidomic Combining DESI Imaging and LESA Mass Spectrometry to Evaluate Metabolic Alterations in Obese Zebrafish Mass Spectrometry Imaging (MSI) enables spatial mapping of metabolites but often lacks in-situ structural confirmation. To address this, we validated a workflow combining histological staining, Desorp...

Spatial Lipidomic Combining DESI Imaging and LESA Mass Spectrometry to Evaluate Metabolic Alterations in Obese Zebrafish #JLipidRes www.jlr.org/article/S002...

This is a Journal of Lipid Research symposium!
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Building better tools to decipher the lipidome Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spectrometry tools for studying complex lipid systems.

Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spec tools for studying complex lipid systems.
www.asbmb.org/asbmb-... #JLipidRes

Building better tools to decipher the lipidome Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spectrometry tools for studying complex lipid systems.

Chemical engineer–turned–biophysicist Matthew Mitsche uses curiosity, coding and creativity to tackle lipid biology, uncovering PNPLA3’s role in fatty liver disease and advancing mass spec tools for studying complex lipid systems.
www.asbmb.org/asbmb-... #JLipidRes

Spatial configuration of the choline group of PC in LPLAT10. A: Multiple sequence alignment of human LPLAT8–10 and docking simulations of LPLAT10 and C26:0-PC. The AGPAT motif 4 and loop domain are represented in a box, whereas the W-X-W motif is represented in a neon-green box. Conserved residues are highlighted in yellow.

X-linked adrenoleukodystrophy is a rare disorder where early diagnosis is critical.

In #JLipidRes, researchers at Teikyo University identified the enzyme that produces C26:0-LPC, a key diagnostic biomarker — advancing precision in rare disease detection.

www.teikyo-u.ac.jp/en/topics/20...

Imaging Bioactive Lipid Isomers in Acetaminophen-Induced Liver Injury using Nano-DESI Tandem Mass Spectrometry Acetaminophen (APAP) overdose is a leading cause of acute liver failure, resulting from the production of a reactive metabolite that induces hepatocyte necrosis. Current clinical treatments for APAP o...

Imaging Bioactive Lipid Isomers in Acetaminophen-Induced Liver Injury using Nano-DESI Tandem Mass Spectrometry #JLipidRes www.jlr.org/article/S002...

An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway. Sphingolipids (SPLs) are bioactive lipids playing vital functions in cellular stress responses. The tumor suppressor p53 has been implicated in regulating few specific SPL enzymes; however, a comprehe...

An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway. #JLipidRes #MassSpec www.jlr.org/article/S002...

Plasma lipidomics and 15-year risk of incident diabetes: A Coronary Artery Risk Development in Young Adults Study Lipid metabolism has long been implicated in diabetes, but there has been a paucity of population-based studies of the plasma lipidome and incident diabetes in cohorts of early-middle age. We used dat...

Plasma lipidomics and 15-year risk of incident diabetes: A Coronary Artery Risk Development in Young Adults Study #JLipidRes #MassSpec www.jlr.org/article/S002...

Figure 3. Mice with adipose-specific deletion of CSN8 display insulin resistance and altered energy homeostasis.

New JLR press| Scientists' data highlights that CSN8/CSN is crucial for maintaining protein homeostasis in adipose tissue.
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Figure 3. Assessment of macrophage beta oxidation and fatty acid synthesis in sham and CKD mice.

New in JLR press| Chronic Kidney Disease Induces Distinct Alterations of Macrophage Lipid Metabolism in a Mouse Model of Atherosclerosis.
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Mass Spectrometry Imaging of Adipose Tissue Lipidome Maps Lineage-Specific Metabolite Profiles Adipocyte subtypes may drive a heterogeneous distribution of lipids in adipose tissue. Adipocytes from the transient receptor potential cation channel subfamily V member 1 (Trpv1) lineage are one such...

Mass Spectrometry Imaging of Adipose Tissue Lipidome Maps Lineage-Specific Metabolite Profiles #JLipidRes www.jlr.org/article/S002...

Spatial Mapping of PUFA Incorporation into Phospholipids with bisallylic deuteration Mass spectrometry (MS) imaging using stable isotope-labeled fatty acids provides a groundbreaking approach to precisely localizing exogenous fatty acids and their metabolites in vivo. However, challen...

Spatial Mapping of PUFA Incorporation into Phospholipids with bisallylic deuteration #JLipidRes #MassSpec www.jlr.org/article/S002...

Fig. 5. 17,18-EpETE does not impair vaccine efficacy OVA mRNA-LNPs with or without 17,18-EpETE or PBS (control) were injected into the gastrocnemius of C57BL/6J mice.

New in JLR press| Scientists' findings suggest that 17,18-EpETE has potential as a supplementary agent to mitigate inflammatory side effects.
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Influence of obesity and insulin resistance with hepatic steatosis on the human plasma lipidome Insulin resistance accompanied by hepatic steatosis is a common complication of obesity. In an effort to identify plasma lipids that could be biomarkers or causes of insulin resistance with steatosis ...

Influence of obesity and insulin resistance with hepatic steatosis on the human plasma lipidome #JLipidRes #MassSpec www.jlr.org/article/S002...

The n-3 PUFA content of the global lipidomes of NIST SRM 2378, SRM 1950 and intra-laboratory quality control materials The regular use of commercially available Standard Reference Materials (SRM) and intra-laboratory quality control (ILQC) materials are important tools for standardizing and ensuring high quality lipid...

The n-3 PUFA content of the global lipidomes of NIST SRM 2378, SRM 1950 and intra-laboratory quality control materials #JLipidRes #MassSpec www.jlr.org/article/S002...

New Multiplex LC-MS/MS Method for lipid biomarker Analysis of Inherited Neurodegenerative Metabolic Diseases A significant number of inherited neurodegenerative metabolic diseases (NMD) arise from altered lipid metabolism, including impaired degradation of sphingolipids and dysfunction in organelle-related m...

New Multiplex LC-MS/MS Method for lipid biomarker Analysis of Inherited Neurodegenerative Metabolic Diseases #JLipidRes www.jlr.org/article/S002...

The image shows RAW264.7 cells, treated with lipopolysaccharide (LPS) and stained with DAPI (blue), apoA1 (red), LAMP1 (green), a marker of lysosomes. The yellow puncta indicate co-staining between apoA1 and LAMP1. Other experiments showed that the HDL receptor SRB1 is degraded via the lysosome in response to LPS.

This #JLipidRes cover shows RAW264.7 cells, treated with lipopolysaccharide and stained with DAPI, apoA1, LAMP1, a marker of lysosomes.

Delve into the paper "HDL attenuates LPS-induced inflammation via SR-B1-mediated lysosomal degradation" by Deng, Haoyu et al.: www.jlr.org/article/....

Sphinganine as a potentially relevant metabolite in pulmonary involvement of primary Sjögren’s syndrome Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and frequent extra-glandular manifestations, with pulmonary involvement b...

Sphinganine as a potentially relevant metabolite in pulmonary involvement of primary Sjögren’s syndrome #JLipidRes #MassSpec www.jlr.org/article/S002...

Figure 1. Alterations in plasma levels of ceramides and glycosphingolipids.

New in JLR press| Scientists' study aimed to elucidate the metabolic profiles of plasma ceramides and glycosphingolipids (GSLs) in Parkinson's disease patients.
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Spatial and Temporal Brain Biodistribution of Neuropathogenic Sphingolipids of Krabbe Disease Glycosphingolipids are essential lipids enriched in the outer leaflet of the plasma membrane, particularly those forming the myelin sheaths. Disorders impacting the glycosphingolipid metabolism cause ...

Spatial and Temporal Brain Biodistribution of Neuropathogenic Sphingolipids of Krabbe Disease #JLipidRes #MassSpec www.jlr.org/article/S002...

Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson’s Disease Alterations in sphingolipid metabolism have been implicated in the pathogenesis of Parkinson's disease (PD), yet findings regarding peripheral sphingolipid changes remain inconsistent. This study aime...

Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson’s Disease #JLipidRes #MassSpec www.jlr.org/article/S002...

Mapping fentanyl’s cellular footprint Using a new imaging method, researchers at State University of New York at Buffalo traced fentanyl’s effects inside brain immune cells, revealing how the drug alters lipid droplets, pointing to new pa...

In a recent study in Journal of Lipid Research, scientists used a new imaging approach to map fentanyl’s effects on brain immune cells. Their findings could transform how addiction is assessed and lead to new diagnostic and therapeutic tools: www.asbmb.org/asbmb-today/.... #ASBMBJournals #JLipidRes

Mapping fentanyl’s cellular footprint Using a new imaging method, researchers at State University of New York at Buffalo traced fentanyl’s effects inside brain immune cells, revealing how the drug alters lipid droplets, pointing to new paths for addiction diagnostics.

In a recent study in Journal of Lipid Research, scientists used a new imaging approach to map fentanyl’s effects on brain immune cells. Their findings could transform how addiction is assessed and lead to new diagnostic and therapeutic tools: www.asbmb.org/asbmb-.... #ASBMBJournals #JlipidRes

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Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation Mutations in microtubule-associated protein Tau (MAPT), the gene that codes for the protein Tau, cause frontotemporal lobar degeneration (FTLD) with phenotypes ranging from behavioral changes to cogni...

Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation #JLipidRes #MassSpec www.jlr.org/article/S002...

Promotional graphic for the 2026 ASBMB Annual Meeting scientific symposium on lipids in cell–cell communication and metabolism in health and disease. It features photos of organizers Nada Abumrad And Michele Alves-Bezerra.

At the #JLipidRes session on #lipids in cell communication and metabolism, speakers will share new insights into signaling, inflammation, immunity and metabolic disease.
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☑️ Late-breaking abstracts open soon!
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Quantification of esterified oxylipins following HILIC-fractionation of lipid classes Several oxylipins are lipid mediators derived from the oxidation of polyunsaturated fatty acids (PUFAs). The majority of oxylipins in biological samples occurs esterified in neutral lipids (nLs) and p...

Quantification of esterified oxylipins following HILIC-fractionation of lipid classes #JLipidRes #MassSpec www.jlr.org/article/S002...

FIGURE 4. Effects of asprosin in metabolic disease markers and liver steatosis.

New in JLR press| Scientists' results showed that in vitro, asprosin reduced expression of lipogenic genes and increased those of fatty acid oxidation and mitochondrial activity in hepatocytes.
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JLR press| Scientists showed an intestinal trophic action of OCA that demonstrates a dual clinical benefit of NR1H4 agonism in the prevention of PNALD in pigs.
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www.jlr.org/article/...
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Orm2 promotes nitrogen-induced sphingolipid production and endocytosis via Orm1 phosphorylation The Orm family proteins inhibits serine palmitoyltransferase —the enzyme that catalyzes the first step in sphingolipid synthesis. In S. cerevisiae, the two Orm proteins are thought to function redunda...

Orm2 promotes nitrogen-induced sphingolipid production and endocytosis via Orm1 phosphorylation #JLipidRes #MassSpec www.jlr.org/article/S002...