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Cover of Molecular & Cellular Proteomics special issue featuring portraits of women scientists in proteomics against a colorful gradient background.

Cover of Molecular & Cellular Proteomics special issue featuring portraits of women scientists in proteomics against a colorful gradient background.

🌍 Join #MolCellProt in celebrating the International Day of Women and Girls in Science!

Women in Proteomics, a new MCP special issue, showcases women driving innovation and discovery in proteome research.

➡️ Read more: www.mcponline.org/wo...
🎨 Luciana Giono
#WomenInSTEM

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Cover of Molecular & Cellular Proteomics special issue featuring portraits of women scientists in proteomics against a colorful gradient background.

Cover of Molecular & Cellular Proteomics special issue featuring portraits of women scientists in proteomics against a colorful gradient background.

🌍 Join #MolCellProt in celebrating the International Day of Women and Girls in Science!

Women in Proteomics, a new MCP special issue, showcases women driving innovation and discovery in proteome research.

➡️ Read more: www.mcponline.org/wo...
🎨 Luciana Giono

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Figure 7. Development of a combinatorial exo-protein diagnostic biomarker panel and assessment of MUC1 exo-protein in plasma-derived EVs.

Figure 7. Development of a combinatorial exo-protein diagnostic biomarker panel and assessment of MUC1 exo-protein in plasma-derived EVs.

New in MCP Press| Circulating extracellular vesicle protein biomarkers for the early detection of high-grade serous ovarian cancer.
Learn more:
www.mcponline.org/ar...
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Antibody array-based proteomic screening of colorectal cancer stool and graphical representation of significantly different proteins in CRC vs HC.

Antibody array-based proteomic screening of colorectal cancer stool and graphical representation of significantly different proteins in CRC vs HC.

#WorldCancerDay research spotlight: "High accuracy stool biomarkers of pre-cancerous colorectal cancer identified using a 2000-plex immunoproteomic screen" by Vanarsa, Kamala et al.

➡️Access the #MolCellProt paper: www.mcponline.org/ar...

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Scientists identify pan-cancer biomarkers Researchers analyze protein and RNA data across 13 cancer types to find similarities that could improve cancer staging, prognosis and treatment strategies. Read about this recent article published in Molecular & Cellular Proteomics.

#WorldCancerDay | Researchers analyze protein and RNA data across 13 cancer types to find similarities that could improve cancer staging, prognosis and treatment strategies.

➡️ Read about this recent article published in Molecular & Cellular Proteomics: www.asbmb.org/asbmb-...
#MolCellProt

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Figure 2. CSF survey PRM assays developed from either Stellar MS linear ion trap (LIT) GPF library or Orbitrap™ (OT) GPF library data.

Figure 2. CSF survey PRM assays developed from either Stellar MS linear ion trap (LIT) GPF library or Orbitrap™ (OT) GPF library data.

New in MCP press| Scientists observe that proteins selected based on their measurement robustness are still able to capture differences in abundance across disease groups in a small sample set.
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www.mcponline.org/ar...
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Fig 4 Heterogeneity of protein abundance in head and neck squamous cell carcinoma.

Fig 4 Heterogeneity of protein abundance in head and neck squamous cell carcinoma.

New in MCP press| An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day.
Learn more:
www.mcponline.org/ar...
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An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...

Inside #MolCellProt via @asbmbjournals.bsky.social: An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day by Klingeberg, Melissa et al.

www.mcponline.org/article/S153...

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Figure 2. Differential protein abundance analysis of plasma samples across irAE groups.

Figure 2. Differential protein abundance analysis of plasma samples across irAE groups.

New in MCP press| plasma Proteome-Driven Liquid Biopsy for Individualized Monitoring and Risk Stratification of Immune-Related Adverse Events in Checkpoint Immunotherapy
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www.mcponline.org/ar...
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This is an immunofluorescent image of the cerebral cortex, showing the progenitor marker SOX2 and the mature neuron marker NEUN.

This is an immunofluorescent image of the cerebral cortex, showing the progenitor marker SOX2 and the mature neuron marker NEUN.

#MolCellProt cover | SOX2+ progenitors & NEUN+ neurons in mouse cortex. Inspired by: Spatial Proteomics Reveals Distinct Protein Patterns in Cortical Migration Disorders Caused by LIN28A Overexpression and WNT Activation: www.mcponline.org/article/S153.... (@asbmbjournals.bsky.social)

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Figure 1. Tandem duplications within exon 3 of AKT1 in JGCTs used in this study.

Figure 1. Tandem duplications within exon 3 of AKT1 in JGCTs used in this study.

New in MCP press| Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model.
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Thank you for sharing! For more from JBC and ASBMB's other journals, you can follow us here. Papers and journal news from JBC, MCP and JLR are posted here.
#JBiolChem #MolCellProt #JLipidRes @asbmbaus.bsky.social

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Scientific symposia

Single-cell proteomics is revolutionizing biology by measuring proteins in individual cells in real time. Join Ileana Cristea (@princeton.edu) for this #MolCellProt symposium at #ASBMB26!
www.asbmb.org/annual-meeti...
☑️ Late-breaking abstracts open soon — submit by Jan. 15: l.feathr.co/ESm5YGn8Ps7w.

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The #ASBMB26 symposium on single-cell proteomics also features:
• Bogdan Budnik, @wyssinstitute.bsky.social
• James Kostas, @princeton.edu
• Jennifer Van Eyk, Cedars-Sinai
➡️Details: www.asbmb.org/annual-meeti....
#MakeItPossible #MolCellProt (@asbmbjournals.bsky.social)

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Promotional graphic for the 2026 ASBMB Annual Meeting scientific symposium on single cell proteomics. It features a photo of organizer Ileana Cristea.

Promotional graphic for the 2026 ASBMB Annual Meeting scientific symposium on single cell proteomics. It features a photo of organizer Ileana Cristea.

Single-cell proteomics is revolutionizing biology by measuring proteins in individual cells in real time. Join Ileana Cristea for this #MolCellProt symposium at #ASBMB26: www.asbmb.org/annual...

☑️ Late-breaking abstracts open soon — submit by Jan. 15: l.feathr.co/ESm5YGn8....

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Proteomics reveals protein shifts in diabetic eye disease Using proteomics, researchers identified protein changes in eye fluid that mark diabetic retinopathy progression and may serve as biomarkers for vision-threatening complications. Read more about this ...

How does diabetic #retinopathy (DR) progress from early damage to serious, vision-threatening disease?
A new #MolCellProt study identified protein biomarkers — including APOB, transferrin & S100A7 — that distinguish nonproliferative diabetic retinopathy, PDR & neovascular glaucoma.
ow.ly/9Aml50Xw1TI

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Extracellular vesicles offer clues to cattle reproduction Extracellular vesicles from pregnant cattle support embryo development better than laboratory models, highlighting their potential to improve reproductive efficiency in bovine embryo cultures. Read more about this recent MCP paper.

@asbmbjournals.bsky.social News | Extracellular vesicles from pregnant cattle support embryo development better than lab models, highlighting their potential to improve reproductive efficiency in bovine embryo cultures.

➡️Read more about this recent #MolCellProt paper: www.asbmb.org/asbmb-....

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Fig. 3. Label-free quantitative proteomics identification for analyzing differential protein expression.

Fig. 3. Label-free quantitative proteomics identification for analyzing differential protein expression.

New in MCP press| findings indicate that heparin and heparan sulfate oligosaccharides with well-defined structures may serve as potential therapeutic agents for liver-related diseases.
Learn more:
www.mcponline.org/ar...
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Figure 1. Schematic representation of non-canonical translation initiation sites.

Figure 1. Schematic representation of non-canonical translation initiation sites.

MCP Press| Chasing the Ghost Proteome in the Dark matter.
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www.mcponline.org/ar...
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Overview of the stepwise filtering and ranking process for the identification of potential O. volvulus biomarkers among human plasma proteomics samples. PSM, peptide-spectral matches.

Overview of the stepwise filtering and ranking process for the identification of potential O. volvulus biomarkers among human plasma proteomics samples. PSM, peptide-spectral matches.

This study identifies a promising set of proteins for developing assays to diagnose onchocerciasis (causing severe dermatitis and blindness) and monitor treatment efficacy: www.mcponline.org/article/S153....

#MolCellProt #BlindnessAwarenessMonth

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This 3D visualization of C4BP was created by Hecklab (Albert Heck) in collaboration with Sensu.health. C4BP uses its eight “legs” to catch proteins related to inflammation, stopping further immune response.

This 3D visualization of C4BP was created by Hecklab (Albert Heck) in collaboration with Sensu.health. C4BP uses its eight “legs” to catch proteins related to inflammation, stopping further immune response.

C4BP-C4b complexes visualized by high-speed atomic force microscopy.

C4BP-C4b complexes visualized by high-speed atomic force microscopy.

#Halloween Trivia 🕸️ Did you know human blood contains spider-shaped proteins that help regulate the innate immune response?
🕷️Discover how C4BP uses its eight “legs” to catch proteins and control inflammation: www.asbmb.org/asbmb-....
#Immunology #MolCellProt #MassSpec

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Improving the productivity and resilience of plants is crucial for addressing the food and climate challenges that the world is facing. This special issue of Molecular and Cellular Proteomics presents a wide range of proteomic studies in plants.
www.mcponline.org/sp...
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Figure 1. Overall workflow of pAb de novo sequencing with intact mass, targeted middle-down, and bottom-up MS data.

Figure 1. Overall workflow of pAb de novo sequencing with intact mass, targeted middle-down, and bottom-up MS data.

MCP press| Scientists present PolySeq.AI, an automated de novo workflow that combines bottom-up, middle-down, and intact mass analysis to accurately sequence pAb samples without relying on external databases."
Learn more:
www.mcponline.org/ar...
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We are pleased to present this collection of recent research articles on proteomics, such as advances in proteomics technology, clinical proteomics and single-cell proteomics.
www.mcponline.org/re...
#molcellprot

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