Mtb ClpP is a heterotetradecameric complex.

JBC review: Fred Goldberg Machines in the Pathogenesis of Mycobacterium #tuberculosis

@heran.bsky.social reviews what is known about how caseinolytic proteases and proteasomes function to contribute to the virulence of one of the world's deadliest pathogens: www.jbc.org/article/S002.... #JBiolChem

📸 @alextoker.bsky.social, Associate Director, BIDMC Cancer Research Institute, at #ASBMB26. Toker also organized the #JBiolChem symposium, exploring biochemical modifications in health and disease, including cancer, cardiovascular and metabolic disorders, and neurodegeneration.

We are pleased to present a curated collection of cutting-edge research articles in the Journal of Biological Chemistry, highlighting innovative discoveries and emerging advances in cancer cell signaling and metabolism.
www.jbc.org/jbc-canc...
#jbiolchem

This is a Journal of Biological Chemistry symposium! #JBiolChem #MakeItPossible

Writers and Readers of Sialylation in Immunoregulation in Cancer Sialic acids are the terminal monosaccharides of the glycocalyx that critically shape cell-cell interactions, and are strongly implicated in regulating immune recognition and tissue homeostasis. In ca...

On #WorldCancerDay 🎗️, our review on Writers and Readers of Sialylation in Immunoregulation in Cancer is out today in #JBiolChem:
🔗 www.jbc.org/article/S002...

Follow for future experimental glyco-work from the @siglecdude.bsky.social lab 🔬🧫 #glycotime

Molecular modelling of TAM+M interaction with hBKCa.

#WorldCancerDay research spotlight: Tamoxifen metabolites acting via BKCa orchestrate the dynamics of K+ and Ca2+ in breast cancer cells by Maier, Selina et al.

➡️Access the #JBiolChem paper: www.jbc.org/article/...

Matrix metalloproteinase inhibitor reduces cancer invasion Scientists at the Mayo Clinic engineered a TIMP-1 protein variant that selectively inhibits MMP-9 and reduces invasion of triple-negative breast cancer cells, offering a promising tool for targeted ca...

On #WorldCancerDay, ASBMB highlights research driving more precise cancer therapies.

In #JBiolChem, Mayo Clinic researchers engineered a TIMP-1 protein variant that selectively inhibits MMP-9 & reduces invasion of triple-negative breast cancer cells.
www.asbmb.org/asbmb-today/...

Matrix metalloproteinase inhibitor reduces cancer invasion Scientists at the Mayo Clinic engineered a TIMP-1 protein variant that selectively inhibits MMP-9 and reduces invasion of triple-negative breast cancer cells, offering a promising tool for targeted ca...

On #WorldCancerDay, ASBMB highlights research driving more precise cancer therapies.

In #JBiolChem, Mayo Clinic researchers engineered a TIMP-1 protein variant that selectively inhibits MMP-9 & reduces invasion of triple-negative breast cancer cells.
www.asbmb.org/asbmb-today/...

New in JBC press| Tamoxifen metabolites acting via BKCa orchestrate the dynamics of K+ and Ca2+ in breast cancer cells.
Learn more:
www.jbc.org/article/...
#jbiolchem

Figure 1. Structural overview of NMDARs. (A) Domain architecture of GluN1. Amino acid sequence of the CaM binding site in GluN1-C0 is indicated in the box. (B) Multiple sequence alignment of human GluN1-C0 with the IQ motif of human CaV1.1 and CaV1.2, and the CaM binding site in the human olfactory cyclic-nucleotide gated channel, CNGA2.

New in JBC press| Structural Basis and Functional Analysis of NMDA Receptor Regulation by Calmodulin.
Learn more:
www.jbc.org/article/...
#jbiolchem

Lamins A and C is required to anchor emerin at the nuclear envelope, and mutations in these proteins cause devastating diseases such as Emery-Dreifuss muscular dystrophy (EDMD). In work now available in #JBiolChem at www.jbc.org/article/S002..., we identify a novel lamin A/C-emerin binding site.

Figure 1. Single-cell RNA-seq identifies BASP1 expression is elevated in chemoresistant OSCC.

New in JBC press| Scientists' study demonstrates that BASP1 acts as a key regulator of EMT in cisplatin-resistant oral squamous cell carcinomas.
Learn more:
www.jbc.org/article/...
#jbiolchem

This JBC cover image depicts HDAC7 (colored protein) bound on chromatin in complex with Histone H3.3.

This #JBiolChem cover depicts HDAC7 (colored protein) bound on chromatin in complex with Histone H3.3.

➡️ Details: Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells by Hassan et al.
www.jbc.org/article/S002...

Fig. 2 | Detection of GPCR surface expression using the PIONEER platform a, Schematic of surface detection using PIONEER.

New in JBC press: "PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators."
Learn more:
www.jbc.org/article/...
#jbiolchem

Protein Kinase A regulates Cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP Cyclooxygenase-2 (COX-2/PTGS2) is an inducible enzyme central to inflammatory responses, and its expression is tightly regulated. Elevated intracellular cAMP levels are known to stimulate COX-2 expres...

Inside #JBiolChem via @asbmbjournals.bsky.social: Protein Kinase A regulates Cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP by Adame-Garcia, Sendi Rafael et al.
www.jbc.org/article/S002...

Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes Genomic instability and loss of proteostasis are two of the primary Hallmarks of Aging. Although these hallmarks are well-defined in the literature, the mechanisms that drive genomic instability and l...

Inside #JBiolChem: Age-dependent topoisomerase I depletion alters recruitment of rDNA silencing complexes by Power, Lindsey N. et al.
www.jbc.org/article/S002...

Collage of molecular structures, fluorescent cell images, and electron microscopy highlighting key biological chemistry research published in the Journal of Biological Chemistry in 2025.

The Year in #JBiolChem 2025 is a virtual issue featuring some of the year’s most impactful research. Highlights span mitochondrial ribosome structure, biomolecular condensate imaging, nucleosome positioning & more.

➡️Assembled by @alextoker.bsky.social & Henrik Dohlman
www.jbc.org/the-year-in-...

The JBC editors are pleased to present The Year in JBC 2025, a retrospective virtual issue showcasing some of the year’s most impactful research.
www.jbc.org/the-year...
#jbiolchem

Figure 1. Illustration of the target site used for in silico docking of virtual compound libraries into the Gα-interaction face of RGS14 and RGS12 (55), based on the archetypal structural model of the RGS4/Gαi1·GDP·AlF4- complex (PDB id1AGR; ref.

Editors' Picks| Developing inhibitors of the guanosine triphosphate hydrolysis accelerating activity of Regulator of G protein Signaling-14
Learn more:
www.jbc.org/article/...
#jbiolchem

Gut microbes hijack cancer pathway in high-fat diets Researchers at the Feinstein Institutes for Medical Research found that a high-fat diet increases ammonia-producing bacteria in the gut microbiome of mice, which in turn disrupts TGF-β signaling and promotes colorectal cancer.

Colorectal cancer ranks as one of the leading causes of cancer-related deaths in the U.S. A study published in #JBiolChem shows that microbial metabolites disrupt transforming growth factor beta signaling to promote CRC & proposes a promising molecular target for CRC therapy.

Figure 1. Approach to identify RARγ gene targets in the context of squamous cell carcinoma.

New in JBC press: "Multiple modes of transcriptional regulation by the nuclear hormone receptor RARγ in human squamous cell carcinoma."
Learn more:
www.jbc.org/article/...
#jbiolchem

Thank you for sharing! For more from JBC and ASBMB's other journals, you can follow us here. Papers and journal news from JBC, MCP and JLR are posted here.
#JBiolChem #MolCellProt #JLipidRes @asbmbaus.bsky.social

An evolutionary T119R substitution in the macaque T-cell immunoreceptor TIGIT enables proteolytic shedding and reveals clinical antibody vulnerabilities Despite being a promising target for cancer immunotherapy, several TIGIT (T-cell immunoreceptor with immunoglobulin and ITIM domain) antibodies have been largely disappointing in human trials. As TIGI...

By Pirillo, Freenor, Wamba, Bhathagar, Mondal, and Tushir-Singh of @ucd-mmi.bsky.social in @asbmb.bsky.social's #JBiolChem.

www.jbc.org/article/S002...

Figure 5. Proposed model of CypD import pathway into mitochondria.

New in JBC press: "Scientists' work highlights the functional versatility of the MIA pathway beyond the intermembrane space."
Learn more:
www.jbc.org/article/...
#jbiolchem

Figure 2. MutS concentration has a larger effect on incision of linear DNA than MutL or MutH concentrations.

New in JBC press: "Tetramerization of the DNA mismatch repair protein MutS enhances daughter strand incision preferentially in the vicinity of replication errors."
Learn more:
www.jbc.org/article/...
#jbiolchem

The first two decades of the 21st century have observed the rapid development of structural biology. In recognition of this fast-moving field, we curate this thematic review series on "supramolecular structures" and present seven timely reviews.
www.jbc.org/thematic...
#jbiolchem

Metabolic and Epigenetic Abnormalities Cause Hepatic Fibrogenesis in Metabolic Dysfunction-Associated Steatohepatitis Model Mice The prevalence rates of liver-related metabolic syndrome, metabolic dysfunction-associated steatotic liver disease (MASLD), and the consequent metabolic dysfunction-associated steatohepatitis (MASH) a...

Metabolic and Epigenetic Abnormalities Cause Hepatic Fibrogenesis in Metabolic Dysfunction-Associated Steatohepatitis Model Mice #JBiolChem #MassSpec www.jbc.org/article/S002...

Cover of the JBC thematic review series on "supramolecular structures" featuring colorful 3D models of various supramolecular biological structures on a blue background.

The first two decades of the 21st century have observed the rapid development of structural biology. In recognition of this fast-moving field, #JBiolChem associate editors curated this thematic review series on supramolecular structures and present seven timely reviews: ow.ly/AvsA50XveNv.

A promotional graphic for the ASBMB 2026 scientific symposium on biochemical modifications in health and disease that includes a photo of organizer by Alex Toker.

Biochemical modifications help control cell function — and their disruption contributes to cancer, metabolic disease and neurodegeneration.

Join the #JBiolChem symposium organized by @alextoker.bsky.social to explore new research and emerging therapeutic insights: ow.ly/GtMz50Xwbo0.

Figure 1. Auxin-inducible degron system to deplete CNOT1 and CNOT4.

New in JBC press: "Scientists' data suggest that CNOT4 exerts opposite effects on mRNA metabolism compared to CNOT1."
Learn more:
www.jbc.org/article/...
#jbiolchem