Hoi1 targets BLTP2 to ER–PM contact sites to regulate #lipid homeostasis. New study from Samantha K. Dziurdzik, Vaishnavi Sridhar, Elizabeth Conibear @lizconibear.bsky.social and colleagues (University of British Columbia): rupress.org/jcb/article/...

#Genetics #MembraneContactSites #ER_literature

Dziurdzik, Sridhar, Conibear et al. identify a conserved adaptor that recruits BLTP2-like proteins to ER–plasma membrane contacts by binding helical projections on their lipid transfer channel to maintain #lipid homeostasis. rupress.org/jcb/article/...

#MembraneContactSites #ER_literature

Kudos to the whole team and @tgalli.bsky.social -- 🙏 for allowing us to collaborate on this super exciting story -- I would also add #stress #organelles -- #ER_literature #proteostasis

In @jcb.org, Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #lipid #ER_literature #LipidDroplets

Zhifang Li et al. reveal that the NRZ tethering complex is a critical regulator of virus-induced ER–LD interactions by enhancing ER–LD contacts, thereby facilitating efficient viral infection. rupress.org/jcb/article/...
#Organelles #Virology #Membrane #lipid #ER_literature #LipidDroplets

#ER_literature

The diverse forms and roles of the neuronal endoplasmic reticulum - Nature Reviews Neuroscience The dynamic and versatile architecture of the neuronal endoplasmic reticulum (ER) enables it to support a wide range of functions. In this Review, Carvalhais, Kole and Kuijpers describe the mechanisms...

A beautiful, informative and perceptive review of neuronal ER, and how its form relates to its function. Nice work from @marijnkuijpers.bsky.social and colleagues. #ER_Literature

Endoplasmic reticulum patterns insect cuticle nanostructure. New study from Sachi Inagaki, Shigeo Hayashi @riken-bdr.bsky.social and colleagues: rupress.org/jcb/article/...

🎦 See video summary by Sachi Inagaki 👉 youtu.be/50JRPysrTNU

#Drosophila #ER_literature #Development #Organelles

Ist2 is a #phospholipid scramblase that links #lipid transport at the ER to organelle homeostasis, say Heitor Gobbi Sebinelli, Camille Syska, Hafez Razmazma, Luca Monticelli, Guillaume Lenoir, Alenka Čopič @umontpellier.bsky.social et al: rupress.org/jcb/article/...

#Biophysics #ER_literature

#ER_literature

#ER_literature

bims-proteo 2025-12-07 papers

A very rich weekly selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: #ER_literature Dynamic Organellar Mapping in yeast reveals extensive protein localization changes during ER stress www.nature.com/articles/s41...

General Trends in the Calnexin-Dependent Expression and Pharmacological Rescue of Clinical CFTR Variants Cystic Fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene ( CFTR ). Though most people with CF have one or two copies of the ΔF508 m...

#ER_literature
www.biorxiv.org/content/10.1...

Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control N-glycosylation is essential for protein folding in the endoplasmic reticulum (ER). Glycan attachment facilitates the binding of newly synthesized pol…

#ER_literature Mannose trimming is the dominant signal for the release of misfolded glycoproteins from ER quality control www.sciencedirect.com/science/arti...

#ER_literature

UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation - Nature Communications ER membranes tune protein degradation to lipid composition. Using reconstitution approaches, the authors show that the ubiquitin conjugating enzyme UBE2J2 senses lipid packing, modulating its own and ...

#ER_literature UBE2J2 sensitizes the ERAD ubiquitination cascade to changes in membrane lipid saturation www.nature.com/articles/s41...

Contact-dependent incorporation of endoplasmic reticulum into retraction fibers and #migrasomes. New study from Peiyao Fan, Yang Chen and colleagues @pku1898.bsky.social: rupress.org/jcb/article/...

#Migration #motility #Biochemistry #Organelles #ER_literature

#ER_literature

#ER_literature

Close-up of vesicular ER exit sites by volume electron imaging using FIB-SEM. New report from Athul Nair, Tom Kirchhausen @kirchhausenlab.bsky.social and colleagues @bostonchildrens.bsky.social: rupress.org/jcb/article/...

#Trafficking #Technology #ER_literature

In @jcb.org, Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...

#ER_literature #Migration #Organelles

Peiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/...

#ER_literature #Migration #Organelles

Lysosomes as a store of amino acids for making new secreted proteins at ER junctions? #ER_Literature

What do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies rupress.org/jcb/article/...
#ER_literature

Navigating lipid droplet proteins – part II: molecular mechanisms underlying ER-to-lipid droplet protein partitioning Lipid droplets (LDs) originate from the endoplasmic reticulum (ER) and are unique among cellular organelles, as they consist of a hydrophobic core of neutral lipids that is surrounded by a phospholipi...

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning

#Organelles
#EndoplasmicReticulum
#ER_Literature

Navigating lipid droplet proteins – part I: ER targeting routes of lipid droplet-destined membrane proteins Lipid droplets (LDs) are cytosolic lipid storage organelles that derive from the endoplasmic reticulum (ER). Their biogenesis and function are essential for maintaining cellular lipid homeostasis and ...

Curious how proteins find their way to #LipidDroplets?

Our bipartite review traces their journey from ER insertion to LD partitioning:

👉 Navigating lipid droplet proteins - part I: ER targeting routes of LD-destined membrane proteins

#EndoplasmicReticulum
#ER_Literature
#Organelles
#Biochemistry

#ER_Literature

Multiple interactions recruit BLTP2 to ER-PM contacts to control plasma membrane dynamics. New study from Anbang Dai @anbangdai.bsky.social, Pietro De Camilli @pdc-lab.bsky.social and colleagues @yaleschoolofmed.bsky.social: rupress.org/jcb/article/...

#Membrane #lipid #Biochemistry #ER_literature

Membrane protein export in developing axons, via axonal ERES and Golgi bypass #ER_Literature

#ER_literature