Check out our video!🥳PLAGL1-IGF2 axis regulates osteogenesis of postnatal condyle development
#PLAGL1 #IGF2 #osteogenesis
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www.nature.com/articles/s41...

Research reveals PLAGL1, a key gene, boosts jawbone growth via the IGF2 pathway, aiding bone-forming cells. Vital clues for treating craniofacial issues!👍
#PLAGL1 #IGF2 #jawbone #gene
@ijosjournal.bsky.social
www.nature.com/articles/s41...

IGF2 Identified as a Critical Regulator of Early Adipose Tissue Development Featured PublicationDiabetes

🔬 Researchers led by Dr. Siegfried Ussar have identified insulin-like growth factor 2 (IGF2) as a central driver of fat tissue expansion during early postnatal development.

👉 Read more: t1p.de/71yka

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#DiabetesResearch #IGF2

Unidirectional Crosstalk Between NTRK1 and IGF2 Drives ER Stress in Chronic Pain Background: Chronic postsurgical pain (CPSP) poses a major clinical challenge due to unresolved links between neurotrophic pathways and endoplasmic reticulum (ER) stress. While Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) modulates ER stress in neuropathic pain, its interaction with Insulin-Like Growth Factor II (IGF2) in CPSP remains uncharacterized, impeding targeted therapy. This study defined the spinal NTRK1-IGF2-ER stress axis in CPSP. Methods: Using a skin/muscle incision–retraction (SMIR) rat model, we integrated molecular analyses and intrathecal targeting of NTRK1 (GW441756) or IGF2 (siRNA). Results: SMIR surgery upregulated spinal NTRK1, IGF2, and ER stress mediators. NTRK1 inhibition reduced both NTRK1/IGF2 expression and ER stress, reversing mechanical allodynia. IGF2 silencing attenuated ER stress and pain but did not affect NTRK1, revealing a unidirectional signaling cascade where NTRK1 drives IGF2-dependent ER stress amplification. These findings expand understanding of stress-response networks in chronic pain. Conclusions: We show that spinal NTRK1 drives IGF2-mediated ER stress to sustain CPSP. The NTRK1-IGF2-ER stress axis represents a novel therapeutic target; NTRK1 inhibitors and IGF2 biologics offer non-opioid strategies for precision analgesia. This work advances CPSP management and demonstrates how decoding unidirectional signaling hierarchies can transform neurological disorder interventions.

Spinal NTRK1→IGF2→ER stress fuels chronic #Postsurgical #Pain 🤯 🔥SMIR rats: block NTRK1 or silence IGF2=pain relief🩹🧬A non‑opioid precision #Analgesia target 🚀 🔬 @mdpiopenaccess.bsky.social #CPSP #NTRK1 #IGF2 #ERstress #Pain
doi.org/10.3390/biom...

Spinal NTRK1→IGF2→ER stress fuels chronic #Postsurgical #Pain 🤯 🔥SMIR rats: block NTRK1 or silence IGF2=pain relief🩹🧬A non‑opioid precision #Analgesia target 🚀 🔬 @mdpiopenaccess.bsky.social #CPSP #NTRK1 #IGF2 #ERstress #Pain
doi.org/10.3390/biom...

Unborn Babies Use Genes From Dad to “Remote-Control” Mothers for Extra Food Scientists at Cambridge have unveiled a fascinating mechanism where fetuses use a paternal gene to control the mother's nutrient release during pregnancy. This "remote control" system involves hormona...

Unborn babies use genes from dad to remote control mothers for extra food #Igf2 #imprinting scitechdaily.com/unborn-babie...