Recta final de inscripciones para el VI Congreso Fatro de Anestesia y Analgesia en Pequeños Animales Con el inicio del Congreso previsto a mediados de abril, el proceso de inscripción se encuentra en su tramo final, con plazas limitadas y alta demanda entre profesionales clínicos ...

Recta final de inscripciones para el VI Congreso Fatro de #Anestesia y #Analgesia en Pequeños Animales

Effect of Continuous Erector Spinae Plane Block on Postoperative Recovery in Patients Undergoing Minimally Invasive Cardiac Surgery: A Prospective, Randomized Controlled Clinical Trial

This study shows that continuous #ESPB supports patients undergoing #MinimallyInvasive #CardiacSurgery, with modest improvements in #QoR15 scores, reduced #PostoperativePain, lower #Opioid use & fewer rescue #Analgesia interventions. #medsky

To read: doi.org/10.1007/s115...

#ESP blocks could not be found to be non-inferior to #paravertebral blocks for #analgesia for #cardiacsurgery with #mediansternotomy

www.bjanaesthesia.org/article/S0007-0912(25)00...

#Research by Zhen Wang, Anqi Wu, Hanli Liu & Yuan Bo Peng concludes that transcranial #photobiomodulation with near-infrared laser induces #analgesia in rats 🧠 🔦

📜 Read the study: physoc.onlinelibrary.wiley.com/doi/10.1113/...

🧠 💻 Have you completed our learning modules?

Module one covers Assessment of the #CriticallyIll patient, referral to #CriticalCare, #Sedation and #Analgesia and much more.

Find out more 🔗 www.scottishintensiv...

#IntensiveCare #IntensiveCareSociety

Breathing new life into pain management: a systematic review of nebulised ketamine for analgesia - Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine Background Acute pain accounts for 60–90% of presentations to the emergency department (ED), with 20–40% of patients reporting severe pain. Current management practices, including simple analgesics,…

link.springer.com/article/10.1...

Breathing new life into #pain management: a systematic review of nebulised ketamine for #analgesia. This review evaluates the efficacy of nebulised ketamine in reducing pain in adult #ED patients, compared to other treatments.

Client Challenge

Mimicking #opioid #analgesia in #cortical #pain #circuits
doi.org/10.1038/s415...

Muy agradecido a Grünenthal España por permitirme opinar sobre los avances en el campo de los #canales_ionicos y su relevancia en el tratamiento del #dolor_cronico y el trabajo de @painchannels.bsky.social en el @neuroalc.bsky.social
lnkd.in/dsvtS2hx

#dolor #neuropatia #quimioterapia #analgesia

Prehospital analgesia for trauma-related pain by paramedics: a comparative retrospective observational study of paracetamol, nalbuphine plus paracetamol, and piritramide - Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine In this retrospective observational study, we compared the efficacy and safety of paracetamol compared with those of nalbuphine plus paracetamol and piritramide in prehospital analgesia for…

#Prehospital #analgesia for #trauma-related pain by paramedics: a comparative retrospective observational study of paracetamol, nalbuphine plus paracetamol, and piritramide

Read #free and #openaccess on #sjtrem
sjtrem.biomedcentral.com/articles/10....

#FOAMed

Effect of Continuous Erector Spinae Plane Block on Postoperative Recovery in Patients Undergoing Minimally Invasive Cardiac Surgery: A Prospective, Randomized Controlled Clinical Trial - Current Medical Science Objective To investigate whether continuous erector spinae plane block (ESPB) improves the quality of recovery (QoR) and decreases postoperative acute and chronic pain in patients undergoing…

This study shows that continuous ESPB enhances recovery quality in patients undergoing #MinimallyInvasiveCardiacSurgery, resulting in reduced #PostoperativePain, #Opioid use, & use of rescue #Analgesia. @fudan-university.bsky.social #medsky

Read:

EXPRESS: Dehydrocorydaline can be a suitable candidate for analgesic purposes: a review on the current preclinical evidence - Mehdi Dehghani, Behrang Nooralishahi, Fatemeh Rezaee Tazangi, 2025 Pain stands as one of the main factors related to human disability and suffering, with different classifications (e.g., acute/chronic, somatic/visceral, and mal...

#Dehydrocorydaline, an #alkaloid from Rhizoma Corydalis, shows strong preclinical potential as a natural #pain reliever with anti-inflammatory and neuroprotective effects. #Analgesia journals.sagepub.com/doi/10.1177/...

So we've gone from no acetaminophen while #pregnant to no #acetaminophen when you need #analgesia!
They're just making it up as they go along and people will #suffer as a consequence. #Cruelty is the point.

Analgesia and silymarin: What are the opportunities and challenges? - Mehdi Dehghani Firoozabadi, Behrang Nooralishahi, Fatemeh Rezaei-Tazangi, 2025 Pain is an unpleasant sensory and emotional sensation about actual or possible tissue damage that can cause remarkable health and economic problems. For pain re...

#Silymarin, a natural flavonoid from milk thistle, shows promise as a safer alternative for pain relief, especially in inflammatory and neuropathic conditions. Its potential synergy with other drugs offers new opportunities in analgesic therapy. #analgesia journals.sagepub.com/doi/10.1177/...

EXPRESS: Honokiol and analgesia: a mechanistic review on the current capacities and challenges - Behrang Nooralishahi, Mehdi Dehghani, Fatemeh Rezaee Tazangi, 2025 Pain is an unfavorable subjective sensation influencing 20% of the public population, giving rise to substantial health and economic issues. Several categories ...

#Honokiol: more than a polyphenol. This mechanistic review highlights its promising analgesic effects in inflammatory, neuropathic, and gouty #pain, alongside anti-cancer, anti-inflammatory, and antioxidant benefits. #Analgesia #Antinociceptive journals.sagepub.com/doi/10.1177/...

🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia.

Potential impact:

👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability

🔗 www.page-meeting.org/default.asp?...

#ChronicPain #Pain

Dr Anoushka Afonso at @mskcancercenter.bsky.social tells @topmedtalk.bsky.social about pioneering work in #ambulatory #surgical care, #enhanced #recovery , non-opioid #analgesia, #personalized #care & Returning to Intended Oncological Therapy (#RIOT) for #cancer patients.

tinyurl.com/p2fnvntx

Continuous nerve blocks for patients who undergo shoulder surgery may provide better #analgesia and lower rates of hemidiaphragmatic paralysis associated with high volume injections. #interscalene #regional #Ansky

#Pain following total knee arthroplasty followed two distinct trajectories in the study by Zhong et al., allowing physicians to predict 1-month opioid and #analgesia requirements within hours to days after #TKA

Sublingual #ketamine for acute #pain: does it offer an effective, #opioid-sparing option for post-operative #analgesia?

bjanaesthesia.org/article/S0007-0912(25)00232-6/

Unidirectional Crosstalk Between NTRK1 and IGF2 Drives ER Stress in Chronic Pain Background: Chronic postsurgical pain (CPSP) poses a major clinical challenge due to unresolved links between neurotrophic pathways and endoplasmic reticulum (ER) stress. While Neurotrophic Tyrosine Kinase Receptor Type 1 (NTRK1) modulates ER stress in neuropathic pain, its interaction with Insulin-Like Growth Factor II (IGF2) in CPSP remains uncharacterized, impeding targeted therapy. This study defined the spinal NTRK1-IGF2-ER stress axis in CPSP. Methods: Using a skin/muscle incision–retraction (SMIR) rat model, we integrated molecular analyses and intrathecal targeting of NTRK1 (GW441756) or IGF2 (siRNA). Results: SMIR surgery upregulated spinal NTRK1, IGF2, and ER stress mediators. NTRK1 inhibition reduced both NTRK1/IGF2 expression and ER stress, reversing mechanical allodynia. IGF2 silencing attenuated ER stress and pain but did not affect NTRK1, revealing a unidirectional signaling cascade where NTRK1 drives IGF2-dependent ER stress amplification. These findings expand understanding of stress-response networks in chronic pain. Conclusions: We show that spinal NTRK1 drives IGF2-mediated ER stress to sustain CPSP. The NTRK1-IGF2-ER stress axis represents a novel therapeutic target; NTRK1 inhibitors and IGF2 biologics offer non-opioid strategies for precision analgesia. This work advances CPSP management and demonstrates how decoding unidirectional signaling hierarchies can transform neurological disorder interventions.

Spinal NTRK1→IGF2→ER stress fuels chronic #Postsurgical #Pain 🤯 🔥SMIR rats: block NTRK1 or silence IGF2=pain relief🩹🧬A non‑opioid precision #Analgesia target 🚀 🔬 @mdpiopenaccess.bsky.social #CPSP #NTRK1 #IGF2 #ERstress #Pain
doi.org/10.3390/biom...

Spinal NTRK1→IGF2→ER stress fuels chronic #Postsurgical #Pain 🤯 🔥SMIR rats: block NTRK1 or silence IGF2=pain relief🩹🧬A non‑opioid precision #Analgesia target 🚀 🔬 @mdpiopenaccess.bsky.social #CPSP #NTRK1 #IGF2 #ERstress #Pain
doi.org/10.3390/biom...

🔬 Highlights include:
•Prof Macfarlane @aberdeenepi.bsky.social: top 0.08% globally in #MSK & back pain 🥼
•Prof Jones @garethjones1.bsky.social: top 0.57% in back pain 🚶‍♂️🚶‍♀️
•Prof Rosemary Hollick: top 6.28% in #osteoporosis 🦴 •Prof Patrice Forget: top 0.82% in #analgesia & #opioid research 🧪💊

🎉Proud to share some incredible 2024 #ScholarGPS rankings for the #Epidemiology Group at
@uniofaberdeen.bsky.social

From #ChronicPain, #Osteoporosis & #MSK health, to #analgesia, #opioid research,& #pandemic preparedness—our team is making an impact worldwide🌍

🔗 www.abdn.ac.uk/iahs/academi...

El #kratom combate el #dolor con una eficacia similar a la morfina pero su eficacia se mantiene más tiempo: la serotonina podría jugar un papel clave:
bmccomplementmedtherapies.biomedcentral.com/articles/10....
+ info en español: kationickratom.net/kratom-dolor/
#analgesia #fitoterapia

La vitamina C podría ayudar a aumentar la #analgesia del #kratom, prevenir el desarrollo de tolerancia y disminuir la severidad del síndrome de retirada: kationickratom.net/potenciar-ef...
#Dolor #Farmacología #Fitoterapia

Actualizan las pautas para el monitoreo de pequeños animales durante la sedación y la anestesia El objetivo es establecer un punto de referencia realista para una atención segura hacia pequeños animales sin perjudicar a las clínicas con menos recursos ...

El Colegio Americano de #Anestesia y #Analgesia #Veterinaria ha revisado y ampliado sus pautas para el monitoreo de #pequeñosanimales durante la #sedación y la anestesia

Analgesics are medications that relieve pain without causing unconsciousness. They work by targeting pain pathways, either by blocking pain signals to the brain, reducing inflammation, or changing how pain is perceived.
#analgesia #painrelief #pharmacology #medstudent #pharmacystudent #VikaasLLC