Weekending using shaders from @blenderkit.bsky.social
Concept inspired by @bradyajohnston.bsky.social
Dynein arms — the ATP-powered engines behind ciliary motion.
#Dynein #Cilia #Axoneme #MolecularBiology #StructuralBiology #CryoEM #ProteinStructure #Biophysics #Blender3D #SciArt #BioArt
A Syd and RUFY #dynein adaptor complex mediates axonal circulation of dense core vesicles, say Viktor Karlovich Lund, Ole Kjaerulff and colleagues @ucph.bsky.social: rupress.org/jcb/article/...
#Trafficking #StructuralBiology #Neuroscience
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. In @jcb.org, van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
#Trafficking
Lund et al. @ucph.bsky.social reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
In @jcb.org, Lund et al. reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
Mechanochemistry of Molecular Motors and Filaments. 8-9 May 2026 at University of Warwick.
Calling all #MotorsInQuarantine fans: Please join us for 1.5 days of science on motors and the cytoskeleton as we celebrate the career of Rob Cross. More info and sign-up here: tinyurl.com/mechanochemi... #kinesin #dynein #myosin #microtubules #actin #cytoskeleton
#Dynein fans, we've got a wonderful #OpenAccess #review #article for you in #CYTOSKELETON! "Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor" . You'll find it here: onlinelibrary.wiley.com/doi/full/10....
📣New CRC 1357 open access article! Congrats go to Simon Wieland & co-authors for their new article "Many dynein teams collectively generate high forces during the transport of large organelles" published in the Biophysical Journal!
doi.org/10.1016/j.bp...
#microplastics #celltransport #dynein
If you are interested in molecular motors this #OpenAccess #review #article in #CYTOSKELETON is for you. #Dynein: A Multifaceted #Therapeutic Target and Its Dysregulation in Aberrant #Cell Proliferation. You'll find it here: onlinelibrary.wiley.com/doi/full/10....
We're excited to promote our range of Dynactin & Dynein complexes this month! Visit the Complex Portal to explore the respective orthologous and paralogous complexes! (ebi.ac.uk/complexporta...) #Dynactin, #Dynein, #Intracellulartransport
CCSer2 gates #dynein activity at the cell periphery, say Juliana Zang, Morgan DeSantis and colleagues @umich.edu: rupress.org/jcb/article/...
#Migration #motility #Biochemistry #Biophysics #Cytoskeleton #Centrosomes #endosomes #zebrafish
Zang, DeSantis et al @umich.edu reveal CCSer2 as a Ndel1 binding protein that regulates #dynein activity at the cell periphery. Loss of CCSer2 disrupts #centrosome positioning & early #endosome trafficking, causing migration defects in developing #zebrafish & cell culture rupress.org/jcb/article/...
Zang, DeSantis et al @umich.edu reveal CCSer2 as a Ndel1 binding protein that regulates #dynein activity at the cell periphery. Loss of CCSer2 disrupts #centrosome positioning & early #endosome trafficking, causing migration defects in developing #zebrafish & cell culture rupress.org/jcb/article/...
Next rockstar talk from Karthika Balasubramaniam (Cynthia He, NUS, SG) on curious roles of PIH homologs in regulation of axonemal #dynein assembly in #Trypanosomes- #DynAPs, chaperoning, (co-)translation, folding in right time & space?! See: www.molbiolcell.org/doi/10.1091/... #ukcilia2025 2/7
11/11
These findings have broad implications for understanding cell–cell interactions, such as those between immune cells and target cells.
#CellAdhesion #Mechanotransduction #Microtubules #Dynein #Integrin #IntegrinAffinity #FluidSubstrates #CellSpreading
Back to real #cilia, which harbour many structural heterogeneities with unknown functions...
doi.org/10.1101/cshp...
Could these contribute to a curvature or state-dependent stiffness that can be dynamically regulated to enhance wave propagation?
#CryoEM & #dynein experts help us search for this!
As we now know, #cilia beating requires the distributed action of #dynein motors along the filament...
Amazingly, a mathematician predicted this doi.org/10.1242/jeb.... (1958) in @jexpbiol.bsky.social before the discovery of dynein! (A few years later Gibbons found it in the protist #tetrahymena)
Ok, for the #dynein part!
This paper was published in @naturecellbiology.bsky.social in 2014, so definitely not recent, but we proposed that dynein-1's stacked conformation is autoinhibitory state for the first time. This model is widely accepted in the field now. www.nature.com/articles/ncb...
Schedule for the 49th e-symposium.
Another AMAZING session for you- on species differences in TZ defects in neuroprogenitors, transporting #dynein motors, ciliary tip #microtubule growth, SMO-PKA structure in HH signaling and Protein Atlas, AI and #SpatialProteomics of cilia diversity! Don't miss this... /fin
