The Immunosuppression Paradox in Multiple Sclerosis: Are We Fueling the Fire by Suppressing Immunity in an Epstein–Barr Virus–Linked Disease? Abstract. Recent studies strongly implicate Epstein–Barr virus (EBV) as a necessary trigger for multiple sclerosis (MS). Longitudinal data show that EBV se

This review explores the paradox of using immunosuppression to treat Epstein–Barr virus–linked multiple sclerosis, suggesting future strategies may need EBV targeted therapies.🧠🦠 #MultipleSclerosis #EBV #Immunology #Neurovirology #Autoimmunity
📄 doi.org/10.1093/ofid...
👤 EVBC member: Anna Onisiforou

Non-polio enterovirus infection and electrophysiological changes in human iPSC-derived neural networks Our results demonstrate that neurotropic NPEVs lead to disruption of spontaneous neural activity in a virus-specific manner, which does not correlate with their replication efficiency.

🧠🦠Excited to share our latest work on non-polio enteroviruses (NPEVs) and their impact on the brain.
#Enteroviruses #Neuroscience #Virology #Neurovirology #InfectiousDiseases
www.thelancet.com/journals/ebi...

Dedicated to Bernhard Dietzschold, whose pioneering rabies research made this work possible. Open access! 🔬
#Rabies #Neurovirology #OpenAccess

Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.

" Here we present a large-scale longitudinal analysis of health records from more than 100 million individuals in the U.S that demonstrates a consistent relationship of VZV reactivation with dementia after controlling for nearly 400 measured characteristics."
#Neurovirology #Alzheimer

Microcephaly-like phenotype triggered by novel reassortant and prototypic Oropouche Virus strains in brain organoids Oropouche virus (OROV) is an emerging arbovirus currently spreading across South America, with increasing reports of neurological manifestations, severe systemic disease, and congenital abnormalities....

#Oropouche and #microcephaly-like phenotypes.

In @biorxivpreprint.bsky.social #OROV infects human #brain #organoids collapsing neural progenitors, disrupting architecture.
Congrats Gabrielle Brum Silva, co-authors
www.biorxiv.org/content/10.1...
#MaternalHealth #Neurovirology #Arboviruses

🦠 What does TBEV entry into neurons look like?

With ISIDORe & CEITEC (Instruct CZ), Bisikalo (Helsinki) used cryo-ET to image TBEV on GLP2R-liposomes—confirming cryo-ET compatibility.

Next: higher-res data to reveal the virus–host interface.

#ISIDORe #TBEV #CryoEM #Neurovirology #Flavivirus

Huge thanks to our amazing collaborators Sam J Wilson, Massimo Palmarini, Yannick Simonin, @arhelnathalie.bsky.social and others for their invaluable contributions! 🙌👏
And special kudos to @jimzphd.bsky.social for conducting this study! 👏🎉
#TeamScience #Virology #Neurovirology

Did something on Monday! 💪🥂🎉 Excited to stay in the lab as Dr. @sciencekaleigh and continue my #neurovirology research at Pitt! 💙💛 #lovevirology

PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Unraveling Hepatitis E virus in neurons: A novel human model shows HEV impacts neurite growth with limited immune response. A step closer to understanding HEV-associated neurological disorders! #VirusBioinformatics #HEV #Neurovirology

📄 doi.org/10.1073/pnas...
EVBC👤: @compvirol.bsky.social