This review examines the #Molecular hierarchy and roles of #SKP2 in #CellularHomeostasis, and maps current #therapeutic strategies, aiming to build a #Translational atlas that supports future SKP2-directed interventions for #Cancer and other disorders.
#OpenAccess: amm-journal.org/index.php/20...

An overview of #ERAD’s role in maintaining #CellularHomeostasis, protein quality control, and in regulating physiological processes, highlighting its therapeutic implications for #ProteotoxicStress- driven diseases.

#OpenAccess: doi.org/10.1038/s413...

This review outlines #ubiquitination as a key regulator of #cellularhomeostasis, its dysregulation in major diseases, and emerging therapeutic strategies including #PROTACs, molecular glues, and clinical advances targeting this pathway.

#OpenAccess in #STTT: doi.org/10.1038/s413...

Granulocyte CSF3 mediates idiopathic #PulmonaryFibrosis by regulating TGF-β, while neutralizing CSF3 mitigates #Fibrosis by inhibiting TGF-β signaling, deactivating myofibroblasts, and restoring the ECM and #CellularHomeostasis. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...