Reviewing the molecular mechanisms governing protein quality & quantity control by #ERAD, its integration with the #UPR and #ERphagy, while highlighting its physio-/pathological implications and strategies for ERAD-related diseases. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation
Deol, K. K. et al.
Paper
Details
#ERAD #Ubiquitination #ProteinDegradation
Video: Are Head CT Scans Overutilized in Emergency Departments?
www.diagnosticimaging.com/view/are-hea...
#radiology #neuroradiology #ERad #CTRad
Wg euch wurde ich blockiert! #schmolllippchenzieh #ERAD!
🚨 New review alert! Our article "SEL1L–HRD1-mediated ERAD in mammals" is now online at Nature Cell Biology. We explore how this central ERAD pathway maintains protein homeostasis in mammals and why it matters for health and disease.
👉 rdcu.be/etk3b
#ERAD #NatureCellBiology #SEL1L #HRD1 #ER
Microtubules do more than move chromosomes—they help clean up cellular messes too. 🧹 Eric Rubenstein of Ball State University shows Kar3 and Vik1 are key to protein quality control via ER-associated degradation.
📖 www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology #ERAD #Proteostasis
Indeed, without CCDC134, Gp96 is hyperglycosylated and undergoes #ERAD degradation, so TLRs cannot be well-folded nor traffic to their corresponding membranes for pathogen detection and signalling.
