Reviewing the molecular mechanisms governing protein quality & quantity control by #ERAD, its integration with the #UPR and #ERphagy, while highlighting its physio-/pathological implications and strategies for ERAD-related diseases. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

Aggregating premalignancy - Nature Reviews Cancer In a recent study, Salomó Coll et al. demonstrate that impaired ER-phagy in Kras-mutant pancreatic acinar cells leads to the accumulation of protein aggregates and disruption of acinar cell homeostasis, thereby cooperating with oncogenic KRAS to promote cellular transformation.

ResearchHighlight🚨
A recent study demonstrates that impaired #ERphagy cooperates with oncogenic KRAS to promote cellular transformation of pancreatic acinar cells.
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#SkeletalMuscle #Mitophagy #ERPhagy

ACTA1-Cre::BNIP3L KO🐭muscle
👉Accumulated Mitochondria
👉⏬glycolytic myofiber ⏬oxidative fiber
👉⏫ #ERPhagy (ER-mCherry/GFP-LC3; ER-Emerald/LysoTracker) ⏬ER Ca2+
👉Centronuclear myopathy

@josephwgordon.bsky.social #Autophagy 2025
www.tandfonline.com/doi/full/10....