This study identifies #Progranulin as a key regulator of #BoneMineralDensity in #PostMenopausalWomen, revealing a positive feedback loop with #estrogen signaling and showing that PGRN loss drives #osteoporosis via ERα degradation.

#OpenAccess: doi.org/10.1016/j.ge...

Progranulin deficiency contributes to postmenopausal osteoporosis by enhancing ubiquitination of estrogen receptor α.
#Progranulin #Osteoporosis #EstrogenReceptor #Ubiquitination #BoneHomeostasis #PostmenopausalHealth
doi.org/10.1016/j.ge...

#Genetic evidence supports therapeutic modulation of #progranulin levels in #AlzheimersDisease

Chloe Robins, John D. Eicher, Jimmy Liu...Chun-Fang Xu @GSK

link.springer.com/article/10.1...

This study finds #Progranulin as a key mediator of estrogen in #BoneMetabolism, showing that its loss after menopause promotes #Osteoporosis by increasing #ERα #Ubiquitination & decreasing expression, opening avenues for novel therapies. #medsky

#OpenAccess: www.sciencedirect.com/science/arti...

The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases - Molecular Neurodegeneration Although different neurodegenerative diseases are defined by distinct pathological proteins, they share many common features including protein aggregation. Despite this commonality, most current thera...

'The role of #endolysosomal #progranulin and #TMEM106B in neurodegenerative diseases'

Hideyuki Takahashi & Stephen M. Strittmatter

molecularneurodegeneration.biomedcentral.com/articles/10....

sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models - Molecular Neurodegeneration Background Haploinsufficiency of the progranulin (PGRN) protein is a leading cause of frontotemporal lobar degeneration (FTLD). Mouse models have been developed to study PGRN functions. However, PGRN ...

'sPLA2-IIA modifies #progranulin deficiency phenotypes in mouse models'

Cha Yang, Huan Du, Gwang Bin Lee...Fenghua Hu

molecularneurodegeneration.biomedcentral.com/articles/10....

Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α

This new study determines the association between #progranulin (PGRN) and estrogen signaling in regulating osteoclastogenesis and #osteoporosis and presents a new therapeutic approach for the treatment of #postmenopausal osteoporosis by targeting PGRN/estrogen receptor α. #medsky

buff.ly/uJ3RLWk