It's been an amazing year for the new PTM field of #MARUbylation - happy that I could get involved first-hand!

RNF114 and RNF166 exemplify a new E3 ligases family that recognizes #MARUbylation –hybrid ADP-ribose/ubiquitin modifications– and extends them with K11-linked polyubiquitin
@jnpruneda.bsky.social @michaelnadbio.bsky.social and colleagues
www.embopress.org/doi/full/10....

Online now - the Spotlight "Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells" from @kfeijszaja.bsky.social and colleagues.

#ADPribosylation #ubiquitination #MARUbylation #crosstalk

authors.elsevier.com/sd/article/S...

Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...

#MARUbylation:
@michaelnadbio.bsky.social @jnpruneda.bsky.social and colleagues find that IFN-β induces the novel post-translational modification, mono-ADP-ribosyl ubiquitylation, on several interferon-stimulated #PARPs such as PARP10, PARP7 and PARP14
www.embopress.org/doi/full/10....