I continue to be astounded by the recent resurgence of intriguing studies revolving around #PARPs and the interplay of ADP-ribosylation with other PTMs! Latest example that we published in @embojournal.org:

@genxbegetsgenz.bsky.social

#parps

Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...

#MARUbylation:
@michaelnadbio.bsky.social @jnpruneda.bsky.social and colleagues find that IFN-β induces the novel post-translational modification, mono-ADP-ribosyl ubiquitylation, on several interferon-stimulated #PARPs such as PARP10, PARP7 and PARP14
www.embopress.org/doi/full/10....