Bruceine A stabilizes #NR4A1 by blocking K48-linked #ubiquitination to suppress NF-κB-driven #inflammation, establishing a protein-stabilization therapeutic paradigm that advances nuclear receptor targeting & opens avenues for #KidneyDrug development.

#STTT: doi.org/10.1038/s413...

Dual Targeting of Orphan Nuclear Receptors NR4A1 and NR4A2 for Nonhormonal Endometriosis Therapy. Read more in #Endocrinology: bit.ly/4hM4Ld2 #NR4A1 #NR4A2 #DIM-3 #Endometriosis @endocrinesociety.bsky.social