An overview of #Ubiquitination and its role in the cardiovascular system, highlighting the links between specific #E3Ligases, DUBs, and #Ubiquitin-like modifiers with #CardiovascularDiseases, opportunities and challenges.

#OpenAccess: doi.org/10.1016/j.ge...

Don't miss out on other great Reviews!
📝 A Review from Shaun Olsen et al on #E3Ligases in signaling and therapeutics
📝 A Review from Joseph Cotruvo et al characterizing #Lanthanide biochemistry
📝 Ana Garcia-Saez et al Review the central role mitochondrial membranes play in cell death pathways
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PhoreMost unveils platform to streamline molecular glue drug discovery - PharmaTimes GlueSEEKER enables rational design of targeted protein degraders

#PhoreMost #molecularglue #drugdiscovery #GlueSEEKER #GlueSEEKERplatform #moleculargluedrugdiscovery #effectorproteins #E3ligases #BioRxiv #novelproteinproteininteractions #smallmoleculedrugs #biologicaldata #smallmoleculedevelopment #moleculargluetherapies
pharmatimes.com/news/phoremo...

Check out this amazing paper from @samuelmaiwald.bsky.social! Congrats to all the authors 🎉

#TRIP12 #E3ligases #SchulmanLab

The crystal structure of the murine TRIM21 PRYSPRY domain in complex with suramin was solved at 1.3 Å resolution. This video shows the conformational changes upon suramin binding. #TRIM21 #E3Ligases #CrystalStructure doi.org/10.1107/S205...