Researchers found that in early prostate cancer, FUS represses #AndrogenReceptor activity and tumor progression, leading to its down-regulation.

Read the paper in Oncogene! 📚

https://go.nature.com/4aII47y

Skip #cellculture with INDIGO Biosciences, INC all-inclusive, #luciferase reporter assay kits with an extensive selection of human and orthologs receptor assays for #drugdiscovery or for #environmental monitoring

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Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression - Molecular Biomedicine Castration-resistant prostate cancer (CRPC) poses a significant clinical challenge, characterized by limited therapeutic options and unfavorable prognosis, particularly among elderly men. Reactivation...

#Research
Histone methyltransferase KMT2D targets the SPOP-G3BP1 axis to enhance AR stability and drive castration-resistant prostate cancer progression doi.org/10.1186/s435...

#AndrogenReceptor #CastrationResistant #Methylation #Signaling #Ubiquitination

Skip #cellculture with INDIGO Bio all-inc, #luciferase reporter assay kits with an extensive selection of human and orthologs receptor assays for #drugdiscovery or for #environmental monitoring 

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Our new work in @embojournal.org ! 🎉

PARP7 creates an ADP-ribosyl degron on chromatin-bound AR, leading to DTX2-mediated degradation and negative feedback in androgen signaling in prostate cancer.

Full: www.embopress.org/doi/full/10....

#ProstateCancer #PARP7 #AndrogenReceptor #TheEMBOJournal

🧠🎉 Customer article spotlight: In male mice, testosterone-activated Glu-mPOA neurons trigger GABA-vlPAG circuits, driving sex-specific conditioned pain hypersensitivity.

Read more:
www.ebraincase.com/sup.../custo...

#Neuroscience
#PainResearch
#SexDifferences
#AndrogenReceptor
#Neurocircuits

New insights from the UCBG 3-06 START trial, a multicentre, randomized phase 2 study, evaluating the anti-androgen darolutamide in AR-positive TNBC

@thelancetoncol.bsky.social

#Onco404 #Cancer #Oncology #BreastCancer #oncsky #medsky #ClinicalTrials #TNBC #AndrogenReceptor #Darolutamide

Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities - Nature Reviews Cancer Androgen receptor (AR) signalling plays an important role in several cancers beyond prostate cancer. This Review highlights the context-dependent functions of AR in non-prostatic malignancies, examini...

#REVIEW 🚨

Here, Dotto & colleagues highlight the context dependent functions of #androgenreceptor (AR) in non-prostate cancers, highlighting the intrinsic function of AR in #cancercells and the #tumourmicroenvironment. They also summarize ongoing AR-targeted clinical trials.

📖👇
bit.ly/3ViHTaV