A general rather than site- & function-specific role for protein modification by ADP-ribosylation?
@kfeijszaja.bsky.social , Roko Zaja and coworkers find that labeling by #PARP7 facilitates ubiquitin-dependent degradation of multiple targets upon proteotoxic stress
www.embopress.org/doi/full/10....

Our new work in @embojournal.org ! 🎉

PARP7 creates an ADP-ribosyl degron on chromatin-bound AR, leading to DTX2-mediated degradation and negative feedback in androgen signaling in prostate cancer.

Full: www.embopress.org/doi/full/10....

#ProstateCancer #PARP7 #AndrogenReceptor #TheEMBOJournal

Bryce Paschal and colleagues show that #PARP7 marks the agonist conformation of androgen receptor for #biquitin conjugation by DTX2 E3 with ADP-ribose reader function, resulting in negative feedback of AR-dependent gene expression
www.embopress.org/doi/full/10....

📣Read the review by D. Slade & colleagues @univie.ac.at on #PARP7 enzymatic properties, biological functions and known substrates, its role in various #cancers, and its targeting by specific inhibitors.

🗞️ doi.org/10.1038/s443...