Skip #cellculture with INDIGO Biosciences, INC all-inclusive, #luciferase reporter assay kits with an extensive selection of human and orthologs receptor assays for #drugdiscovery or for #environmental monitoring

🔗 tinyurl.com/yc69sreh

#GLP1R #CB1R #AndrogenReceptor #biotech

New research reveals how CB1 receptors shape angiotensin II–induced vasoconstriction in atherosclerosis. Using an LDLR–CB1R double knockout mouse model, this study offers new insights into vascular remodelling under high-fat diets.
doi.org/10.1556/2066...
#Atherosclerosis #CB1R #DHS #AKJournals

Skip #cellculture with INDIGO Bio all-inc, #luciferase reporter assay kits with an extensive selection of human and orthologs receptor assays for #drugdiscovery or for #environmental monitoring 

🔗www.stratech.co.uk/our-partners/indigo-bios...

#GLP1R #CB1R #AndrogenReceptor #bioscience

✨Exciting to see clinical efficacy of peripheral #CB1R antagonism with #monlunabant. It will expand armamentarium for #obesity with an oral 💊therapy and a different mechanism than incretins ( #GLP1 #GIP)💉

⚡️Similar efficacies in all tested oral doses encourage testing lower doses to optimize safety.

🧵2️⃣ ⚡️Therapeutic target identification⚡️

📌 CB1R regulates #CD206-expressing macrophages and releases of #profibrotic mediators (IL-6, IL-4, LIF, GM-CSF, CXCL10, CCL7, CCL11, IGF-1).

📌 Inhibition of #CB1R in #AlveolarMacrophages attenuates #fibrogenic activation of Macrophages.

Structural mechanism of CB1R binding to peripheral and biased inverse agonists - Nature Communications Peripherally restricted CB1 inhibitors retain the weight loss benefits of this drug class while sparing the negative psychiatric side effects. The authors here elucidate cryo-EM structures of CB1…

CB1R binding insights reveal structural mechanisms of peripheral and biased inverse agonists, offering a path to safer obesity treatments without central side effects. #Science #CB1R #ObesityResearch PMID:39695122, Nat Commun 2024, @NatureComms