Resat Cinar

@resatcinar.bsky.social

9 months ago

🧵4️⃣ ⚡️Therapeutic modality to improve antifibrotic efficacy⚡️

📌 #Zevaquenabant attenuates multiple #fibrosis-related pathways in lungs

📌 Pulmonary delivery of zevaquenabant attenuated #fibrogenic #macrophages expressing Spp1, Trem2, Tgfb1, Mertk, Fabp5, Cd9, Cd63, Gpnmb, Fabp4

Resat Cinar

@resatcinar.bsky.social

9 months ago

🧵2️⃣ ⚡️Therapeutic target identification⚡️

📌 CB1R regulates #CD206-expressing macrophages and releases of #profibrotic mediators (IL-6, IL-4, LIF, GM-CSF, CXCL10, CCL7, CCL11, IGF-1).

📌 Inhibition of #CB1R in #AlveolarMacrophages attenuates #fibrogenic activation of Macrophages.