SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer In tamoxifen-sensitive breast cancer, SIRT7 deacetylates ERα at lysines 302 and 303, promoting CHIP-mediated, ubiquitin-dependent proteasomal degradation of ERα and thereby restraining estrogen-drive...

#Article in #MedComm_Oncology

Researchers from HunanUniversity find that #SIRT7 Orchestrates Ligand-Dependent ERα Signaling Rewiring to Drive #Tamoxifen Resistance in #ERα-positive #BreastCancer doi.org/10.1002/mog2...

#Deacetylation #DrugResistance

❓Tech Q&A | #Cre activation is reversible; the gene KO event is not
🔸Cre-ER(T2) activation is reversible when #tamoxifen is removed, Cre activity returns to an inactive state
🔸DNA recombination at #loxP sites is permanent
🔸Once the target gene is excised at genomic level, the KO is irreversible

Removal of cytotoxic tamoxifen from aqueous solutions using a geopolymer-based nepheline–cordierite adsorbent

This Open Chemistry study presents the synthesis of a novel #Geopolymer-based nepheline–cordierite composite with excellent adsorbent capability for the removal of #Cytotoxic #Tamoxifen from aqueous solutions. #WaterPollutants #WastewaterTreatment

#OpenAccess: doi.org/10.1515/chem...

A new study found that women with very early-stage DCIS who took tamoxifen alone had higher recurrence rates than expected.

youtu.be/BxuHU5Kb_pM

#DCIS #BreastCancer #LowRiskDCIS #BreastCancerResearch #Oncology #MedicalOncology #BreastCancerAwareness #CancerResearch #Tamoxifen

How fasting boosts breast cancer therapy A discovery in mice reveals why fasting enhances a type of breast cancer treatment — a hormone-signalling pathway and gene-expression changes have key roles.

Endocrine therapy against breast tumours that express oestrogen receptor-α is boosted by clinically supervised fasting. This study clarifies the mechanism. #BreastCancer #Tamoxifen www.nature.com/articles/d41...

Supplementation of Tamoxifen with Low-Dose Endoxifen in Patients with Breast Cancer with Impaired Tamoxifen Metabolism (TAMENDOX): A Randomized Controlled Phase I/II Trial AbstractPurpose. :Tamoxifen undergoes bioactivation to its active metabolite (Z)-endoxifen, which blocks estrogen-dependent breast tumor growth at high potency. We tested the feasibility and safety of...

📢 The #TAMENDOX study #GBG91 has been published in #CCR, presenting new evidence on optimizing #endocrine therapy in patients with impaired #tamoxifen metabolism.

Read full text here: aacrjournals.org/clincancerre...

DLL1-responsive PD-L1+ tumor-associated macrophages promote endocrine resistance in breast cancer Triple combination therapy reverses endocrine resistance driven by DLL1high tumor cells, which recruit immunosuppressive PD-L1+ TAMs sustaining CSCs.

Researchers in #ScienceTranslationalMedicine identify tumor-associated macrophages that drive resistance to targeted therapies such as #tamoxifen in ER-positive #BreastCancer, which can be suppressed with immunotherapy targeting PD-L1 and DLL1 to shrink tumors in mice. https://scim.ag/4oFbYyk

🦃Our November Issue is now out 🥧

📗 Cover: Cabezudo et al. IF staining in HEK293T of WAC, a regulator of mTORC1 in response to glucose and glutamine availability

🔦 Explore the contents here

🔓https://buff.ly/BaMtm3s

#Biochemstry #T2DM #mTORC1 #scRNAseq #Tamoxifen #ProstateCancer

Best Of: Finding Dora Richardson, The Forgotten Developer of Tamoxifen, a Lifesaving Breast Cancer Therapy - Episode Two When ICI decided to terminate the breast cancer research, the team went underground.

When her company gave up on tamoxifen, Dr. Dora Richardson didn’t. Her quiet persistence helped create a drug that saved countless lives from breast cancer. Katie Couric introduces the English episode, and Laura Gómez narrates it in Spanish.
#Tamoxifen #WomenInSTEM #BreastCancerAwareness

Encontrando a Dora Richardson – La desarrolladora olvidada del tamoxifeno, una terapia vital contra el cáncer de mama – Episodio dos Cuando ICI decidió cancelar la investigación sobre el cáncer de mama, el equipo continuó en secreto.

Cuando su empresa abandonó el tamoxifeno, la Dra. Dora Richardson no lo hizo. Siguió trabajando — en silencio y con perseverancia — en un fármaco que terminaría salvando innumerables vidas. Narrado por Laura Gómez.

#Tamoxifen #BreastCancerAwareness #HistoriaDeLaCiencia #MujeresEnLaCiencia

Enhanced therapeutic efficacy of Tamoxifen against breast cancer using extra virgin olive oil-based nanoemulsion delivery system Breast cancer remains a leading cause of cancer-related deaths worldwide, requiring innovative therapeutic approaches. This study investigated the development and characterization of an olive…

An oil-in-water #Nanoemulsion system containing #Tamoxifen & extra virgin olive oil [NE(OST)+TMX], enhances therapeutic efficacy of TMX, highlighting its potential as a biocompatible delivery platform against #BreastCancer.

Nanotechnology Reviews #OpenAccess:

For the first time, a non-hormonal medicine has been shown to reduce the number of hot flashes in women with a history of breast cancer who are on hormonal therapy. 💊 https://bit.ly/4pqHUaz

#BreastCancerSurvivor #Menopause #BreastCancer #HotFlashes #BreastCancerResearch #Tamoxifen #Elinzanetant

Tamoxifen Linked to Uterine Cancer via Direct PI3K Activation

A study in Nature Genetics finds tamoxifen can directly activate the PI3K pathway, bypassing PIK3CA mutations, which may explain its association with uterine cancer. Read more: getnews.me/tamoxifen-linked-to-uter... #tamoxifen #pi3k #uterine

Mice study uncovers breast cancer drug side effect Researchers from Germany and the US have discovered how the breast cancer drug tamoxifen can increase the risk of tumours in the uterus, in a study using mice.

Scientists from the Berlin Institute of Health at EARA member Charité have discovered how the breast cancer drug tamoxifen can increase the risk of tumours in the uterus, in a study using mice.
Learn more: www.eara.eu/post/mice-st...
#cancer #breast #uterus #mice #AnimalResearch #tamoxifen

Harvard Study Finds That Drug Commonly Used to Treat Breast Cancer Actually Causes Uterine Tumors! - Thailand Medical News

Harvard Study Finds Drug ( #Tamoxifen ) Commonly Used to Treat #BreastCancer Causes Uterine Tumors!

There is a need to find drugs to combine that blocks these risks.

Study published in peer-reviwed journal Nature Genetics.

Referencing below:

www.thailandmedical.news/news/harvard...

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Kan jag prova nypon mot min artros? Kort svar - ja, du kan testa nypon för din artros. Eftersom du tar Tamoxifen antar jag att det var en hormonkänslig tumör, som var beroende av det kvinnl

Kort svar - ja, du kan testa nypon för din artros. #fytoöstrogen #nypon #Tamoxifen
bit.ly/4lvt7Zi

Is Tamoxifen Chemotherapy? Understanding Its Role in Breast Cancer Treatment - OncoDaily Tamoxifen is not chemotherapy. Learn how it works, its role in hormone-positive breast cancer, and why it's classified as endocrine therapy.

Is Tamoxifen Chemotherapy? Understanding Its Role in Breast Cancer Treatment

oncodaily.com/drugs/tamoxi...

#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #BreastCancer #Tamoxifen #Chemotherapy

Wegen Zusatzkosten: Droht eine Rücknahme von Metformin? Aktuell meldet der »Spiegel«, dass Generikahersteller erwägen, Metformin-haltige Präparate vom Markt zu nehmen, falls eine Neuregelun...

Wenn diese Medikamente für Millionen Menschen so wichtig sind, dann muss es eine Regelung geben, dass die Mehrkosten f.d. Aufbau einer 4. Reinigungsstufe von der Allgemeinheit übernommen wird.

#metformin #antibiotika #Amoxicillin #Tamoxifen

www.pharmazeutische-zeitung.de/droht-eine-r...

After breast cancer (single mastectomy), I have been taking tamoxifen and noticed about something.

Unfortunately, I started having more cavities….

It’s said tamoxifen doesn’t cause them but it might affect indirectly since tamoxifen make my mouth dry….

Ugh 🫠

#tamoxifen #sideeffect #cavities

"Auch andere essenzielle Medikamente wie das Antibiotikum #Amoxicillin oder das Brustkrebsmedikament #Tamoxifen könnten betroffen sein. Erste Berechnungen zeigen, dass die Kosten für diese Wirkstoffe durch die UWWTD um bis zu 116 Prozent steigen könnten."

Taking a carcinogen drug to prevent recurrence of cancer is wild. #Tamoxifen #IHateIt

I'm strong, but it's still hard living with the pain of all the treatments/operation that I have been through, but i am grateful to still be here #cancer #breastcancer #chemotherapy #chemo #radiotherapy #tamoxifen #abemaciclib

Does anyone have #tamoxifen stories they can share? I’m debating the merits vs the crazy side effects

Das war sie, die letzte #Tamoxifen 🥳 Der Onkologe meinte, dass es schon so 2-3 Wochen dauern kann bis ich Veränderungen wahrnehme. Ich bin sehr gespannt. Immerhin schlafe ich schon etwas besser und Panikattacken sind bislang auch keine mehr aufgekommen. Kann gerne weiter so bergauf gehen😁📈

Results from the #NRG Oncology/RTOG 9804 and #ECOG-ACRIN E5194 Trial for Good risk #DCIS INDEED reinforced the role of #RT to reduce ITR since Tam benefit was limited to ipsilat IR _ #RTx more tolerable than 5yrs of #Tamoxifen @sabcs.bsky.social @oncoalert.bsky.social @oncodaily.bsky.social

Honouring an Unsung Chemist, Dora Richardson, Who Transformed Cancer Care - OncoDaily Honouring an Unsung Chemist, Dora Richardson, Who Transformed Cancer Care / Arthur Walpole, Breast Cancer, cancer, cancer treatment, Dora Richardson, Imperial

Honouring an Unsung Chemist, Dora Richardson, Who Transformed Cancer Care

oncodaily.com/insight/dora...

@uclofficial.bsky.social

#BreastCancer #Cancer #CancerTreatment #Medicine #Health #ImperialChemicalIndustries #OncoDaily #Oncology #Tamoxifen #UCL

a woman laying in bed with the words i 'm just so tired above her head ALT: a woman laying in bed with the words i 'm just so tired above her head

#breastcancer #tamoxifen
The tiredness is a beast that is holding me captive.

Tamoxifen Response Rate Influenced by Gut Microbiome The gut microbiome impacts tamoxifen, which explains why 50% of women with breast cancer don’t respond to the treatment.

#MedSky🧪 #publichealth #pharmasky this study shown that variability in the #gutmicrobiome can impact the #pharmacokinetics of #tamoxifen, which could explain 50% of women with #breastcancer don’t respond to Rx that reduces the risk of cancer recurrence
www.insideprecisionmedicine.com/topics/oncol...

A little glance at my cancer journey, always happy to answer any questions on #chemo, #coldcaps, #radiotherapy, #masectomy, #abemaciclib, #tamoxifen #breastcancer #cancer