Supplementation of Tamoxifen with Low-Dose Endoxifen in Patients with Breast Cancer with Impaired Tamoxifen Metabolism (TAMENDOX): A Randomized Controlled Phase I/II Trial AbstractPurpose. :Tamoxifen undergoes bioactivation to its active metabolite (Z)-endoxifen, which blocks estrogen-dependent breast tumor growth at high potency. We tested the feasibility and safety of...

📢 The #TAMENDOX study #GBG91 has been published in #CCR, presenting new evidence on optimizing #endocrine therapy in patients with impaired #tamoxifen metabolism.

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