Discovery of spectabilide A, a new cytotoxic cyclic lipodepsipeptide from Stanjemonium spectabile revealed by OSMAC-guided metabolomics The biosynthetic potential of the fungal epiphyte Stanjemonium spectabile, isolated from the endemic plant Bupleurum gibraltaricum (Granada, Spain), was investigated combining OSMAC (One Strain, Many ...

Discovery of spectabilide A, a new #cytotoxic cyclic lipodepsipeptide from Stanjemonium spectabile revealed by OSMAC-guided #metabolomics

doi.org/10.3897/arph...

Removal of cytotoxic tamoxifen from aqueous solutions using a geopolymer-based nepheline–cordierite adsorbent

This Open Chemistry study presents the synthesis of a novel #Geopolymer-based nepheline–cordierite composite with excellent adsorbent capability for the removal of #Cytotoxic #Tamoxifen from aqueous solutions. #WaterPollutants #WastewaterTreatment

#OpenAccess: doi.org/10.1515/chem...

Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes Protein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.

Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!

In vitro evaluation of antibacterial activity and associated cytotoxicity of biogenic silver nanoparticles using various extracts of Tabernaemontana ventricosa The development of innovative nanocomposites and their applications to a range of goods and technologies with antimicrobial properties has received increasing interest. However, recently, researchers…

This study demonstrates the #GreenSynthesis of silver #Nanoparticles (AgNPs) using the flower and leaf extracts of Tabernaemonta ventricosa and highlights its promising #AntiBacterial and #cytotoxic effects.

#OpenAccess in Green Processing and Synthesis:

This study demonstrates an eco-friendly and sustainable method for the #GreenSynthesis of copper oxide (Cu4O3) #nanoparticles by using pumpkin seed extract, highlighting its potential #AntiBacterial and #Cytotoxic effects.

#OpenAccess: doi.org/10.1515/ntre...

Discovery of #new bianthrones and #chlorinated bianthrones with #cytotoxic activity against cancer cells from #Penicillium hispanicum guided by #HSQC-based DeepSAT
doi.org/10.1080/2150...
@tandfresearch.bsky.social

Check out this upcoming Global Health (HIGH) Rounds hosted by #UCSDHIV and #SDCFAR on February 21, 2025, at 8AM PT! The seminar features Viral Immunologist, Dr. Brad Jones who will discuss ways to harness #cytotoxic T cells to eliminate clonally expanded #HIV reservoirs.

Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms Bacteria engineered for intratumoral delivery of IFN-γ synergize with PD-1 blockade to overcome tumor-intrinsic immune resistance.

Last month in #Science #Immunology, Nicholas Arpaia's group engineered #EColi w genomically integrated synchronized lysis circuit for quorum-regulated delivery of #IFNg! Strain promoted #antitumor immunity in mice, polarizing #TAMs, #cytotoxic #TCells, & #NKCells & augmented #PD1 blockade!