🧫 Importantly, tumor microenvironment cues, including IFNγ signaling, upregulate PARP14 expression and enhance metastatic traits, highlighting a context-dependent role in EwS dissemination.

#tumormicroenvironment #TME #IFN #IFNgamma #IFNg

An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection Stat1 gain-of-function mice fail to resolve inflammation in viral infection because of insufficient early STAT4–IFN-γ responses.

Now in #Science #Immunology: Philips, O'Shea, &al. made mice w human pathogenic #STAT1 activating mutation. Mice had #IFNg -dependent #autoimmunity, but their innatelike lymphocytes produced suboptimal IFNg during viral infection. Exogenous IFNg🚫virus-induced lethality, suggesting possible therapy!

Human LY9 governs CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis Impaired CD4+ T cell–dependent IFN-γ immunity in humans with LY9 deficiency underlies tuberculosis.

This week in #Science #Immunology: Boisson-Dupuis, @casanovalab.bsky.social, & colleagues identify in 3 unrelated individuals w/ #tuberculosis a rare autosomal recessive complete deficiency in #LY9 linked to impaired #IFNg production by CCR4−CCR6+CXCR3+T-bet+RORγT+ TH1* cells (aka TH1/17 cells)!

Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ Interferon-γ chimeric autoantibody receptor T cells broadly deplete autoreactive B cells against interferon-γ.

ICYMI: earlier this month in #Science #Immunology, Ping Chih-Ho & Cheng Lung-Ku labs engineered #CAART cells bearing truncated #IFNg mutant bait to eliminate #Bcells expressing anti-IFN neutralizing #autoantibodies (nAIGAs) in both mouse models & in ex vivo cultures of PBMCs from patients w/ nAIGAs!

IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy We used patient samples and a murine model to understand the contribution of Bregs to EoE immunopathology. We find that Breg-derived IL-10 is important for controlling EoE, but that Breg expansion an....

Check out our new #OpenAccess paper on how #IFNg impairs regulatory B cells in #EoE!

IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy - Clement - Allergy - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

How are immune responses regulated in #EoE? In short: #IFNg is bad and #Bregs are good!

Learn this and more in our new paper out soon in #Allergy!

This work will lay the foundation for improving regulation in #EoE.

BIG thanks to #FoodAllergyFund, #APFED, #AAAAI, #TheHartwellFund and our donors!

Treg depletion:
- ⬆️ meningeal IFNg response
- ⬆️ T and NK cell infiltration in the brain, particularly in the hippocampus (Lymphocyte invasion seemed independent of BBB disruption)
- blocked differentiation & caused neural stem cell death
- impaired memory
#Tregs #IFNg (7/12)

Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms Bacteria engineered for intratumoral delivery of IFN-γ synergize with PD-1 blockade to overcome tumor-intrinsic immune resistance.

Last month in #Science #Immunology, Nicholas Arpaia's group engineered #EColi w genomically integrated synchronized lysis circuit for quorum-regulated delivery of #IFNg! Strain promoted #antitumor immunity in mice, polarizing #TAMs, #cytotoxic #TCells, & #NKCells & augmented #PD1 blockade!

RT: @tauss Absage der Computerspielen. #IFNG ist eine Schande für KA. Veranstalter hat vor dem schwarz-grünen Mob zu früh kapituliert :(