🧫 Importantly, tumor microenvironment cues, including IFNγ signaling, upregulate PARP14 expression and enhance metastatic traits, highlighting a context-dependent role in EwS dissemination.
#tumormicroenvironment #TME #IFN #IFNgamma #IFNg
🌤️ Still’s & MAS Biomarkers 🧬
🔥 IL-18 > 5000 pg/mL → hallmark; IL-18-dominant = MAS-prone, IL-6 = arthritis type.
Triad: IL-18 + S100 + Ferritin = max diagnostic power.
IFN-γ axis drives MAS — CXCL9 drop = response.
🎯 IL-18 defines Still’s; CXCL9 tracks MAS.
#BlueSkyRheum #ACR25 #MAS #IL18 #IFNgamma
