Improved outcome of #HSCT in #STAT1 gain-of-function disease following JAK inhibition bridging. A new report from Emilie Pauline Buddingh, Catharina Schuetz et al.
rupress.org/jhi/article/...
#Autoimmunity #InbornErrorsofImmunity #Immunodeficiencies #Therapeutics

An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection Stat1 gain-of-function mice fail to resolve inflammation in viral infection because of insufficient early STAT4–IFN-γ responses.

Now in #Science #Immunology: Philips, O'Shea, &al. made mice w human pathogenic #STAT1 activating mutation. Mice had #IFNg -dependent #autoimmunity, but their innatelike lymphocytes produced suboptimal IFNg during viral infection. Exogenous IFNg🚫virus-induced lethality, suggesting possible therapy!

A #STAT1 #STAT3 master class from Alejandro Villarino
@upenn.edu IGG.

Study in Mice Links Immune System to ADHD, Neurobehavioral Conditions Building on research that has linked immune responses with certain neurobehavioral conditions, researchers at Duke Health have identified how a key infection-fighting function is involved in triggerin...

A new Duke study identifies how an infection-fighting function triggers hyperactive behavior, adding insight to a switch for genes called #STAT1. This gene regulator plays a key role in the immune system’s response to infections and has also been implicated in disorders such as #autism and #ADHD.

Immune System Gene Linked to Hyperactivity, ADHD and Autism - Neuroscience News Researchers have uncovered a link between the immune gene regulator STAT1 and hyperactive behaviors in mice, offering new insights into neurodevelopmental disorders like autism and ADHD.

🧠 Immune System Gene Linked to Hyperactivity, #ADHD and #Autism

By @dukepress.bsky.social

#Neuroscience #Genetics #STAT1 #Psychology #ASD
neurosciencenews.com/stat1-hypera...