Human LY9 governs CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis Impaired CD4+ T cell–dependent IFN-γ immunity in humans with LY9 deficiency underlies tuberculosis.

This week in #Science #Immunology: Boisson-Dupuis, @casanovalab.bsky.social, & colleagues identify in 3 unrelated individuals w/ #tuberculosis a rare autosomal recessive complete deficiency in #LY9 linked to impaired #IFNg production by CCR4−CCR6+CXCR3+T-bet+RORγT+ TH1* cells (aka TH1/17 cells)!