Leukemia study restores silenced gene in mice. Could it point to new treatments for humans? Researchers created a CRISPR-based tool to pinpoint genes the cancer turns off

A key cancer-fighting gene in leukemia is switched off—not broken—and, in a study published in @science.org #ScienceTranslationalMedicine, scientists from JAX have found a way to switch it back on. 🧬🧪

https://go.jax.org/AMLswitch

Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses B cell responses that bound to future H1N1 and influenza B virus strains, but not H3N2 strains, were elicited in adults by the 1994 influenza vaccine.

By analyzing a “time capsule” of historic samples from recipients of a 1994 influenza vaccine, researchers have defined the breadth of antibody and B cell responses to future, emerging influenza A and B.

Learn more in #ScienceTranslationalMedicine: scim.ag/4sIzkVC

A person wearing protective eyewear and gloves conducts an experiment in a laboratory. The image includes text: "Leukemia study restores silenced gene in mice. Could it point to new treatments for humans?" The Jackson Laboratory logo is visible

A key cancer-fighting gene in leukemia is switched off—not broken—and, in a study published in @science.org #ScienceTranslationalMedicine, scientists from JAX have found a way to switch it back on. 🧬🧪

https://go.jax.org/AMLswitch

Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses B cell responses that bound to future H1N1 and influenza B virus strains, but not H3N2 strains, were elicited in adults by the 1994 influenza vaccine.

By analyzing a “time capsule” of historic samples from recipients of a 1994 #influenza vaccine, a team defines the breadth of antibody and B cell responses to future, emerging influenza A and B.

Learn more in #ScienceTranslationalMedicine: https://scim.ag/3PWpH7d

Extremely privileged to have our study featured on the issue cover which we designed with the latented team @scistories.bsky.social #ScienceTranslationalMedicine!

@katherinekedz.bsky.social
@thedohertyinst.bsky.social

Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses B cell responses that bound to future H1N1 and influenza B virus strains, but not H3N2 strains, were elicited in adults by the 1994 influenza vaccine.

Flu vaccination does more than protect against viruses circulating that year.

Our study published in #ScienceTranslationalMedicine showed historic 1994 vaccine generated broad immune responses against future H1N1 & FluB strains, but not H3N2, spanning 30 years.
www.science.org/doi/10.1126/...

The cover image illustrates how influenza vaccination, represented as an umbrella, offers broad but incomplete protection from infection, represented by falling influenza virus particles.

The new issue of #ScienceTranslationalMedicine is out!

Featuring the winner of the 2026 BII & Science Translational Prize for Innovations in Women's Health, a "time capsule" of samples sheds new light on the breadth of flu vaccine immunity, and more. https://scim.ag/4taZbVW

An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans An oral prodrug of the neurosteroid drug allopregnanolone shows enhanced bioavailability while retaining pharmacology in a clinical trial.

A team in #ScienceTranslationalMedicine applies their Glyph prodrug delivery platform to bypass liver metabolism and deliver allopregnanolone directly to the gut lymphatic system, achieving effective oral delivery in large animals and a phase one trial. https://scim.ag/3PwS384

Quantifying myocardial oxygen consumption and efficiency with motion-resolved cardiac MRI A noninvasive, noncontrast, clinically viable technique assesses myocardial oxygen dynamics.

By repurposing BOLD-MRI neuroimaging for the heart, a team in #ScienceTranslationalMedicine presents a needle-free, high-resolution #MRI technique that can accurately quantify myocardial oxygen consumption in large animals and patients with heart failure in just 3 minutes. https://scim.ag/3NpNtrB

The cover illustration depicts erythrocytes (red) carrying mRNA-loaded lipid nanoparticles (LNPs, blue spheres on erythrocytes) homing to the spleen, where they are phagocytosed by myeloid cells (large blue cells) to deliver chimeric antigen receptor (CAR)–encoding mRNA for in vivo generation of CAR myeloid cells.

A rapid, noninvasive MRI test for heart oxygenation could aid the fight against heart failure, an oral drug delivery platform that bypasses liver metabolism shows promise in animals and a phase 1 trial, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4t7ElqC

Lowering the HTT1a transcript as an effective therapy for Huntington’s disease in a knockin mouse model Lowering the HTT1a transcript delays the onset of molecular and neuropathological phenotypes in a knockin mouse model of Huntington’s disease.

Researchers in #ScienceTranslationalMedicine show that lowering the highly toxic Htt1a transcript with siRNA delays huntingtin (HTT) aggregation and corrects transcriptional dysregulation more effectively than targeting full-length, mutant HTT. https://scim.ag/3NwoFy4

Blood-brain barrier disruption, traumatic encephalopathy, and cognitive decline in retired athletes Blood-brain barrier disruption is associated with cognitive decline and complement system activation in retired athletes.

Traumatic head injuries from collision and combat sports disrupt the blood-brain barrier and trigger inflammation for years after retirement, shows a new MRI and transcriptomic analysis of retired athletes.

Find out more in #ScienceTranslationalMedicine: scim.ag/40Ejq2m

Blood-brain barrier disruption, traumatic encephalopathy, and cognitive decline in retired athletes Blood-brain barrier disruption is associated with cognitive decline and complement system activation in retired athletes.

Traumatic head injuries from collision and combat sports disrupt the blood-brain barrier and trigger inflammation for years after retirement, shows a new MRI and transcriptomic analysis of retired athletes.

Find out more in #ScienceTranslationalMedicine: https://scim.ag/4sT4kC4

Contents | Science Translational Medicine 18, 841

Head trauma from sports can disrupt the blood-brain barrier for years in retired athletes, a highly toxic mutant protein could offer a more effective target in Huntington's disease, and more this week in #ScienceTranslationalMedicine.

scim.ag/475NQ15

The cover image shows oligodendrocyte precursors (OPCs) transduced with a lentivirus encoding an inhibitor of the microRNA miR-126a-3p (green) and stained for myelin basic protein (red). Nuclei are shown in blue.

Head trauma from sports can disrupt the blood-brain barrier for years in retired athletes, a highly toxic mutant protein could offer a more effective target in Huntington's disease, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4busk7z

Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle–mediated mRNA delivery in preclinical models Coinjection of an amino acid cocktail with LNPs enhanced in vivo delivery efficacy and improved preclinical mRNA therapy outcomes.

Amino acid supplementation enhances the uptake of lipid nanoparticles carrying #mRNA therapies in vitro and in mice, suggesting this simple approach could overcome delivery efficacy roadblocks in mRNA #GeneTherapy.

Learn more in #ScienceTranslationalMedicine: https://scim.ag/4ul12ZL

Contents | Science Translational Medicine 18, 840

Studies of uterus transplant recipients reveal how immune cells shape pregnancy outcomes, an amino acid cocktail enhances nanoparticle delivery of therapeutic mRNAs in mice, and more this week in #ScienceTranslationalMedicine.

scim.ag/4lgZbkw

Reconstitution of the uterine immune milieu after uterus or hematopoietic stem cell transplantation Functional reconstitution of the endometrium occurs after both uterus and HSC transplantation, and male immune cells can replenish the uterine niche.

How does the uterine immune system recover after transplant?

A team in #ScienceTranslationalMedicine studies uterine transplant and stem cell transplant recipients and shows that all immune cell lineages reconstitute despite a drop in NFAT signaling. https://scim.ag/4bqtzEL

The cover illustration depicts an mRNA-loaded lipid nanoparticle (LNP; textured sphere) interacting with a cell membrane (pink bilayer), surrounded by space-filling chemical structures representing an amino acid supplement that enhances cellular LNP uptake and mRNA expression.

Studies of uterus transplant recipients reveal how immune cells shape pregnancy outcomes, an amino acid cocktail enhances nanoparticle delivery of therapeutic mRNAs in mice, and more this week in #ScienceTranslationalMedicine. https://scim.ag/3N6ee45

Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice Vaccinating with a stabilized H5 hemagglutinin increases the proportion of humoral responses against neutralizing receptor binding site epitopes.

Researchers in #ScienceTranslationalMedicine present new vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. https://scim.ag/4aRgrcG

Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and enable noninvasive detection of liver fibrosis and cirrhosis.

A noninvasive test can detect liver cirrhosis and other non-cancerous disorders in multiple cohorts by searching for cell-free DNA markers in the fragmentome, laying the road for a flexible, multidisease liquid biopsy.

Check out the study in #ScienceTranslationalMedicine: scim.ag/4uaVtNm

A systems immunology approach reveals divergent immune profiles of RSV and SARS-CoV-2 infections in infants RSV and SARS-CoV-2 infections induce similar interferon but distinct inflammatory, epigenetic, and natural killer cell responses in infants.

Leveraging systems immunology, researchers characterize the distinct immunological profiles produced by #RSV and #SARSCoV2 infections in infants, providing data that explain clinical divergences and could inform future therapeutics. #ScienceTranslationalMedicine https://scim.ag/46XY2IK

Cell-free DNA fragmentomes for noninvasive detection of liver cirrhosis and other diseases Genome-wide cfDNA fragmentomes are altered in liver disease and other morbidities and enable noninvasive detection of liver fibrosis and cirrhosis.

A noninvasive test can detect liver cirrhosis and other non-cancerous disorders in multiple cohorts by searching for cell-free DNA markers in the fragmentome, laying the road for a flexible, multidisease liquid biopsy.

Learn more in #ScienceTranslationalMedicine: https://scim.ag/4ub6qP7

The cover image shows an H5 influenza hemagglutinin (HA) protein carrying stabilizing mutations (magenta).

A noninvasive "fragmentome" test expand liquid biopsy to liver cirrhosis and other conditions, stabilized flu immunogens could improve vaccine efficacy for H5 influenza, and more this week in #ScienceTranslationalMedicine. https://scim.ag/4rN9eAx

Lymphatic disruption drives lung transplant fibrosis through interleukin-1–mediated hyaluronan accumulation Interleukin-1–mediated hyaluronan synthesis in transplanted grafts promotes fibrotic remodeling because of lymphatic disruption.

New work deciphers how disruptions to #lymphatic drainage drive fibrosis in transplanted lungs and hearts through the accumulation of hyaluronan—and identifies potential therapeutic targets to prevent lung fibrosis in mice. #ScienceTranslationalMedicine https://scim.ag/3ONyh7H

Contents | Science Translational Medicine 18, 838

This week's issue of #ScienceTranslationalMedicine is out!

A study uncovers potential therapies for fibrosis in transplanted organs, scientists reveal how infections with SARS-CoV-2 or RSV elicit distinct immune signatures in infants, and more.

scim.ag/4rzOCvj

www.science.org/toc/stm/18/8...

The cover depicts the hexapeptide DLST-6P (orange red) preferentially engaging a regulatory T (Treg) cell (foreground, blue).

This week's issue of #ScienceTranslationalMedicine is out!

A study uncovers potential therapies for fibrosis in transplanted organs, scientists reveal how infections with SARS-CoV-2 or RSV elicit distinct immune signatures in infants, and more. https://scim.ag/3MFEMcf

Baloxavir alleviates severe disease and viremia in ferrets infected with avian- or bovine-origin influenza A(H5N1) virus Treating A(H5N1) influenza virus–infected ferrets with baloxavir resulted in greater survival, decreased viremia, and reduced neurotransmission.

The recently approved anti-influenza drug baloxavir improves survival and reduces viremia in ferrets with severe #H5N1 infections when given before or after exposure, especially when administered via multiple doses. #ScienceTranslationalMedicine https://scim.ag/4rT2TTA

Antibody cocktails based on the occupationally acquired immunity of pediatricians neutralize and confer protection against RSV and hMPV Antibody cocktails derived from pediatricians cooperatively neutralize and protect rodents against RSV and hMPV by targeting conserved epitopes.

By isolating immune cells from pediatricians, researchers in #ScienceTranslationalMedicine employed rational design to engineer cocktails of monoclonal antibodies that neutralize #RSV and #metapneumovirus in rodents without generating resistance. https://scim.ag/4rZKe8J

The 18 February 2026 cover of Science Translational Medicine. The cover shows liver tissue from a mouse lacking the myotubularin gene, a model of X-linked myotubular myopathy, that was fed a diet resembling pediatric formula. The image demonstrates aberrant localization of the bile acid export pump in dark brown and loss of hepatocyte shape and polarity. Nuclei are stained blue.

The new issue of #ScienceTranslationalMedicine is out!

Clues from pediatricians' immune cells lead researchers to new antibody therapeutics for RSV and metapneumovirus, a newly approved anti-influenza drug shields ferrets from severe H5N1, and more. https://scim.ag/4qFzlYs