Sugar Storm: O-GlcNAc signaling amid the clouds of cancer complexity Abstract. Cancer is a systemic disease driven not only by cell-intrinsic alterations, but also by system-wide factors that regulate its initiation and prog

Sugar Storm: O-GlcNAc signaling amid the clouds of cancer complexity
#glycotime #Glycobiology

Cytosolic mannosyltransferases involved in the endoplasmic reticulum N-glycosylation pathway exhibit bacterial ancestry Si Xu, Shuai Chen, Yu-He Gu, Yi-Fan Huang, Hideki Nakanishi, Xiao-Dong Gao; Cytosolic mannosyltransferases involved in the endoplasmic reticulum N-glycosyl

Cytosolic mannosyltransferases involved in the endoplasmic reticulum N-glycosylation pathway exhibit bacterial ancestry
#glycotime #Glycobiology

Best Practices in O-GlcNAcylation: A Survey-Based Consensus Among Researchers Abstract. O-GlcNAcylation is a dynamic and reversible post-translational modification contributing to various cellular processes and diseases. Despite its

Best Practices in O-GlcNAcylation: A Survey-Based Consensus Among Researchers
#glycotime #Glycobiology

New bioRxiv preprint from the BioF:GREAT team!

www.biorxiv.org/content/10.6...

Glydentify — a deep learning to predict sugar donor usage across GT-A/GT-B glycosyltransferases 🍭🤖

Congrats to co-first authors Ruili Fang & Lan Na!

#NSF #BioFGREAT #Glycobiology #GlycoTime #AIinScience

Exploratory analyses of cervicovaginal mucus O-glycan composition and microbiota profiles in unexplained infertility Abstract. In addition to the specific causes of infertility, two components of the vaginal ecosystem, the vaginal microbiota and the cervicovaginal mucus (

Exploratory analyses of cervicovaginal mucus O-glycan composition and microbiota profiles in unexplained infertility
#glycotime #Glycobiology

Development of a Specific and Sensitive LC-MS/MS Method to Quantify Heparan Sulfate 3-O-Sulfotransferase-1 Activity Abstract. Heparan sulfate (HS) is a highly sulfated glycan that regulates diverse biological processes through specific sulfation patterns. Among these, 3-

Development of a Specific and Sensitive LC-MS/MS Method to Quantify Heparan Sulfate 3-O-Sulfotransferase-1 Activity
#glycotime #Glycobiology

Great to attend the Biofoundry session at ACS Spring 2026🧪!

Thanks to George Heintz & Zhao Huimin for organizing and inviting BioF:GREAT.

Also, thanks to Sydney Bedillion, Ruili Fang & Digantkumar Chapla for great flash talks! 🚀

#NSF #BioFGREAT #Glycobiology #GlycoTime #Biofoundry

N-glycan mass spectrometry imaging – a valuable tool for biomarker discovery and validation Abstract. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) enables spatially resolved detection of diverse biomolecules di

N-glycan mass spectrometry imaging – a valuable tool for biomarker discovery and validation
#glycotime #Glycobiology

Polysialic acid is associated with immune activation in human peripheral blood nuclear cells Abstract. Immune dysregulation is a persistent state in which cells of the immune system become activated at low levels for long periods of time. If left u

Polysialic acid is associated with immune activation in human peripheral blood nuclear cells
#glycotime #Glycobiology

Resources for screening the literature for glycan-related terms using PubAnnotation in GlyCosmos Abstract. To facilitate access to relevant text of literature related to data in GlyCosmos, we have developed a collection of annotated literature resource

Resources for screening the literature for glycan-related terms using PubAnnotation in GlyCosmos
#glycotime #Glycobiology

Integrative structural analysis of lacto-N-fucopentaose I recognition by antibodies R-17F and R-13E using NMR, docking, and molecular dynamics simulations Abstract. Anti-glycan antibodies have become essential tools in biochemical assays, tissue staining, and diagnostic applications; however, the structural b

Integrative structural analysis of lacto-N-fucopentaose I recognition by antibodies R-17F and R-13E using NMR, docking, and molecular dynamics simulations
#glycotime #Glycobiology

RT Parastoo Azadi @CCRCUGA Advance your expertise in carbohydrates, glycoproteins, and glycomics through our hands-on, laboratory-focused training at the

RT Parastoo Azadi @CCRCUGA Advance your expertise in carbohydrates, glycoproteins, and glycomics through our hands-on, laboratory-focused training at the #CCRC.

ast.uga.edu/training-in-...

#glycotime #glycoscience #glycomics #MassSpec #NMR #glycobiology #ResearchTraining #UGA

Hypofucosylation promotes pertussis toxin binding to cell surface glycococonjugates and pertussis toxin-induced intracellular ERK signaling Abstract. Pertussis (whooping cough) is caused by the bacterium Bordetella pertussis. Among the virulence factors produced by B. pertussis, pertussis toxin

Hypofucosylation promotes pertussis toxin binding to cell surface glycococonjugates and pertussis toxin-induced intracellular ERK signaling
#glycotime #Glycobiology

Structural Determinants of Site-Specific Core Fucosylation in Human Transferrin: Insights from Crystallography and Molecular Dynamics Abstract. Core fucosylation of N-glycans, catalyzed by fucosyltransferase 8 (FUT8), plays a crucial role in various biological processes; however, the stru

Structural Determinants of Site-Specific Core Fucosylation in Human Transferrin: Insights from Crystallography and Molecular Dynamics
#glycotime #Glycobiology

25] Facts About: Mitochondrial Glycoproteins

In our latest Interesting Fact Post learn about Mitochondrial Glycoproteins!
Think #mitochondria don't have #glycoproteins? Think again! New research shows O-GlcNAc modifications are key to: Energy Brain Health, Development

Read: research.bidmc.org/ncfg/blog/25...

#Glycobiology #glycotime

🔬Trouble expressing glycoside hydrolases or glycosyltransferases? BioF:GREAT can help!

JP Gourdine’s lab (Lewis & Clark College) now expresses🧪 GFP-tagged GH enzymes using our GH platform—empowering undergrads & accelerating research🍭.

biofgreat.org

#BioFGREAT #NSF #Glycoscience #Glycobiology

Profiling Protein-Binding Glycosaminoglycan Oligosaccharides Using a Simple Label-Free Electrophoretic Assay Abstract. Glycosaminoglycans (GAGs) interact with numerous proteins to regulate key biological processes such as coagulation, cell migration, and growth fa

Profiling Protein-Binding Glycosaminoglycan Oligosaccharides Using a Simple Label-Free Electrophoretic Assay
#glycotime #Glycobiology

Structural determinants of glycosaminoglycan oligosaccharides as LL-37 inhibitors in breast cancer Abstract. The human antimicrobial peptide LL-37 exerts a dual role in cancer, promoting tumor progression in breast carcinoma by stimulating calcium influx

Structural determinants of glycosaminoglycan oligosaccharides as LL-37 inhibitors in breast cancer
#glycotime #Glycobiology

YouTube Share your videos with friends, family, and the world

clip - Gordan Lauc on a pill to replace IVIG (IV immunoglobin) therapy
youtube.com/clip/Ugkx_Iw...

If this existed, there would not be as much need for #PlasmaDonation

#glycobiology #immunology #aging

🚀 Join the GlySpace Alliance Webinar – Feb 17 | 10 AM (Zoom)

Hear from BioF:GREAT’s Dr. Lance Wells on democratizing glycoscience + Dr. Rene Ranzinger on new GlyGen v2.10 tools!

See you there!

#BioFGREAT #Glycoscience #Glycobiology #GlyGen #NSF

🚀 BioF:GREAT at #ACSSpring2026!

We’re excited to be speaking in two sessions in Atlanta:

🧬 Biofoundry Session — Tues, Mar 24
🧪 BioF:GREAT Symposium — Wed, Mar 25

Keynotes by Rui Kong & Richard Drake + 12+ talks from the BioF:GREAT team!

#NSF #BioFGREAT #Glycoscience #Glycobiology #GlycoTime

International Conference on Emerging Trends in Glycoscience and Glycotechnology (ETGG) Report, 2025 IE=Edge

International Conference on Emerging Trends in Glycoscience and Glycotechnology (ETGG) Report, 2025
#glycotime #Glycobiology

Effect of domain architecture and non-native F-type lectin domains on a Streptosporangium roseum α-L-fucosidase IE=Edge

Effect of domain architecture and non-native F-type lectin domains on a Streptosporangium roseum α-L-fucosidase
#glycotime #Glycobiology

Efficient mucin O-glycan degradation by specific mucin degrading intestinal bacteria: towards understanding enzyme-glycan interactions Abstract. Intestinal mucin glycan-degrading bacteria are important for mucus turnover, stimulating mucus production, and producing beneficial metabolites.

Efficient mucin O-glycan degradation by specific mucin degrading intestinal bacteria: towards understanding enzyme-glycan interactions
#glycotime #Glycobiology

Water-Guided Docking Improves Prediction of Protein–Glycan Complexes Abstract. Accurate prediction of structure of protein–carbohydrate complexes remains a significant challenge in structural glycobiology, largely due to the

Water-Guided Docking Improves Prediction of Protein–Glycan Complexes
#glycotime #Glycobiology

ASBMB names 2026 fellows The American Society for Biochemistry and Molecular Biology announced that it has named 16 members as 2026 fellows of the society.

Congrats to BioF:GREAT's very own, Lance Wells @docgatordawg1.bsky.social for being named as one of ASBMB's 2026 Fellows!!! 🧪🍭

www.asbmb.org/asbmb-today/...

#NSF #BioFGREAT #Glycobiology #Glycoscience #GlycoTime

BioF:GREAT & CCRC are excited to host Dr. Vlad Panin (Texas A&M) for an upcoming seminar!

🗓 Feb 11 | ⏰ 12:30 PM
📍 CCRC Auditorium

“Unraveling Protein O-mannosylation in the nervous system & regulation of RPTPs” 🍭 🧪

#NSF #BioFGREAT #Glycobiology #Glycoscience #GlycoTime

🎉 Congratulations to Emeritus Professor Tony Bacic (La Trobe) on being named an Honorary Member of the Australian Glycoscience Society! 🎉

#Glycoscience #Glycobiology #AustralianGlycoscienceSociety #AGS

An AI generated image showing a dense forest of glycans on the surface of the cell.

Have you ever wondered how many N-Glycans or #glycoproteins there are on cells?

The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!

Read the full blog post: research.bidmc.org/ncfg/blog/24...

#glycobiology #glycotime #cells #biology

🎊 We're pleased to share today’s article from our #Highlights2025.

🩸 Blood group O expression in normal tissues and tumors

Discover the article, here ➡️ buff.ly/aVyHnPd

#Hantigen #glycanantibodies #lampreyantibodies #glycobiology #fucose