From fate to form: the journey to whole-embryo spatial transcriptomics
In this 'Behind the paper' feature, @yinanwan.bsky.social shares the inside story of an ambitious journey with @schierlab.bsky.social & co.
thenode.biologists.com/from-fate-to...
Very grateful to everyone who made this work possible. I feel incredibly lucky to have worked with such an amazing team.
Special thanks to: Jakob El Kholtei, KJ Jenie, @mcolomerr.bsky.social, and of course our wonderful collaborator Bogdan Bintu and my mentor @schierlab.bsky.social
Very happy to see this out. π @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
I'm thrilled to announce that I'll be starting my lab as a SNSF starting grant professor at the Center for Integrative Genomics in Lausanne! I'm looking for PhD students who are fascinated about the neuronal basis of behaviour across species @fbm-unil.bsky.social
π₯ Piping hot; fresh from the oven! Fever-like conditions accelerate immune cell speed and efficiency through thermoregulation of actomyosin contractility. Congrats to Ivan Company-Garrido, @alempheius.bsky.social, and @mcolomerr.bsky.social on this huge collaborative effort.
And very excited from a personal note to share what started as a summer internship in 2018 in the Wieser and Ruprecht lab, and finished with my co-first author paper in DevCell β¨
With an in-vitro fast system, we found that even small temperature increases (1-2Β°C) are sensed by different immune cells. This rapid and reversible thermo-response depends on Myosin II activity, revealing a conserved thermokinetic mechanism for immune cell motility π₯
#immunecell #cellbio #myosin
At low temperature, cells are weakly recruited with weak Myosin II activity and move slowly. At body temperature, recruitment and Myosin II activity are normal, giving normal cell speed. At fever-like temperature, recruitment and Myosin II activity are strong, resulting in fast cell movement.
Effective immune responses rely on efficient leukocyte migration, but how does temperature regulate this process?
Using #zebrafish embryos and mouse tissue explants, we show that temperature positively regulates leukocyte migration speed, exploration, and recruitment to wounds and lymph vessels π¬
Ever wonder what happens to immune cells when we get a fever? Exicted to share our paper showing that temperature regulates immune cell migration via myosinII! A wonderful collaboration with Ivan, @alempheius.bsky.social, @valeriaventurini.bsky.social & all co-authors!
bit.ly/48XRVGj
Are you interested in a PhD in the area of "Mechanisms of translational control during embryogenesis?" Apply now for a PhD @mpi-cbg.de! Overview of all participating RGLs: imprs.mpi-cbg.de/5761/researc...
Thrilled to share π Iβm starting my lab at University of Zurich,
DMLS as Assistant Professor (tenure track) from Jan 2026!
The Neural MorphoGenomics & Developmental Dynamics Lab will be exploring how genes + morphogenesis shape brain development with organoids, imaging & spatial genomics π§ π¬π§¬
Now published @natecoevo.nature.com with @annika-nichols.bsky.social, our latest on the evolution of π΄ππ¦π¦π± across π²π¬ ππ½π²π°πΆπ²π of cichlid fishes! doi.org/10.1038/s415...
with members of the @schierlab.bsky.social and Salzburger labs, as well as the burgeoning Shafer lab @uoftcellsysbiol.bsky.social
Amazing work!!! Congratulations π₯³
We (schierlab.bsky.social and Seelig lab) are very happy to share that our work has found a home at DevCell cellpress.bsky.social! Free access here: authors.elsevier.com/sd/article/S...
What are the features in 5β² UTRs that determine when and how much of a protein to make during embryogenesis?
