Drosophila lab folks - does anyone have a recommendable software/system for storing information on your fly lines? I will (fingers crossed!) start my own lab fly collection next year and the Di Talia lab is currently trying to move from excel sheets with multiple tabs to something more searchable.
🚨 We are recruiting postdocs! If you're interested in reproductive, stem cell/developmental biology, and/or women's health, please apply! 📝 Please repost! 🚩
More info here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Her interdisciplinary approach to science, her fearlessness to tackle her questions with new approaches, and certainly her style are things I can only hope to emulate. Congrats to Lucy - so well deserved!
Which was of course the best decision. I'm certainly not biased when I say Stanford Dev Bio is the best place ever to get a PhD. Full of curious, brilliant, and supportive mentors like Lucy.
Lucy was the one who called me to tell me I got into her department at Stanford for grad school, and I had to say yes on the phone right then and there!
But like all of Lucy's fascinating and impressive stories, I didn't take it as a brag, but rather my first data point that Lucy was an incredible person to know, learn more about, and be influenced by.
When I interviewed for grad school at Stanford, it was just a few days after Lucy had won the Presidential Medal of Science, and I was greeted by a story and a photo of her with President Obama when I first walked into her office.
As one of the many trainees influenced by Lucy Shapiro, congratulations and thank you for establishing the incredible Dev Bio department at Stanford. Thank you for being a role model, and thank you for your service to our field and the world.
5 dynamical systems concepts every developmental biologist needs to know! This came out of the 2023 Morphogenesis Program. @pauformosa.bsky.social @perez-carrasco.bsky.social
journals.biologists.com/dev/article/...
An illustration of a woman standing at a dead end looking at different roads and buildings. Text reads: My academic job offer was rescinded. I’ll keep going—but U.S. researchers are running out of road.
"I can’t predict the next hiring cycle or the next election. But I can keep doing the science I love while I still have a bench." #ScienceWorkingLife scim.ag/4lXUwDa
Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...
Oh no!! Sorry Jongmin
Thank you so much!
Yes! I believe I have filled out the form
These posts about my work and why it's important are reaching outside the bluesky bubble. Go do it!
I also wrote up a lay summary of the manuscript we just uploaded to biorxiv on facebook. These two interactions with my local community got tons of engagement, and I am now being featured by my old middle school on their fb page and a local news group called AllOnGeorgia.
Inspired by many folks on here and the #McClintockLetters @cornellasap.bsky.social I'm super excited that my op-ed is now available in The Summerville News in Chattooga, Co. GA!
But integration isn’t sufficient anywhere. In sog mutants (where BMP is low and broad), cells outside the normal domain exhibit higher than normal integrated BMP but activate less transcription.
How? The transcription factor Zen modulates the signaling threshold for activation, lowering the barrier for transcription activation.
We found that gene expression domains are best predicted by integrated BMP signaling over time, not instantaneous levels, enabling rapid responses to small changes in signaling levels.
We made a live reporter of BMP activity coupled with MS2 reporters of target gene transcription to understand how cells convert dynamic signaling into gene expression domains.
Thus, cells interpret dynamic morphogen signals through the combined action of temporal integration and spatial competence, providing a framework for robust pattern formation on fast developmental timescales.
But integration isn’t sufficient anywhere. In sog mutants (where BMP is low and broad), cells outside the wild type domain exhibit higher than normal integrated BMP but activate less transcription.
How? The transcription factor Zen modulates the signaling threshold for activation, lowering the barrier for transcription activation.
We found that gene expression is best predicted by integrated BMP signaling over time, not instantaneous levels, enabling rapid responses to small changes in signaling levels.
Excited to share the bulk of my postdocotoral work from the @ditalialab.bsky.social on how cells interpret dynamic morphogen signaling during development! Many thanks to our collaborators & coauthors @shelbyflies.bsky.social, Massimo Vergassola, Jacqueline Janssen, and Anna Chao.
:( my favorite bookmarked webpage
These are fantastic talks! What a fun and inspiring break from paper writing this week. Thank you for posting.
